Level of Cytokines and C3 Complement in the Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Durations.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI:10.1007/s10517-024-06177-x

D V Skripkina, A Yu Abramova, B B Shoibonov, I V Alekseeva, E V Nikenina, S S Pertsov

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Abstract

The parameters of the cytokine profile and functional activity of the complement system in the blood of rats were studied during different time periods of chronic unpredictable mild stress using a model of sequentially alternating low-intensity stress effects for 1, 2, 3, and 4 weeks. In the dynamics of observation, a general tendency towards multidirectional fluctuations in the concentration of cytokines was revealed: an increase in IL-10, but a decrease in IL-4 in comparison with the control. Statistically significant changes in the level of IL-10 were noted after 2, 3, and 4 weeks, IL-4 - after 2 and 4 weeks of stress loads. The percentage of lysis of the C3 component in rats gradually increased by the 2nd week of chronic stress, but then decreased and practically did not differ from the control values (intact animals) by the end of the study. These results illustrate the specificity of changes in the indicators of the C component of the complement system and the cytokine profile of the blood reflecting activity of the cellular and humoral components of the immune response in rats exposed to repeated stress factors of different origins and duration.

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不同持续时间的慢性不可预测应激条件下大鼠血液中的细胞因子和 C3 补体水平

在不同时间段的慢性不可预知的轻度应激期间，研究人员利用一个连续交替的低强度应激效应模型，对大鼠血液中的细胞因子谱参数和补体系统的功能活性进行了研究，应激效应的持续时间分别为1、2、3和4周。在动态观察中发现，细胞因子的浓度总体上呈多向波动趋势：与对照组相比，IL-10 增加，但 IL-4 减少。经过 2、3 和 4 周后，IL-10 的水平发生了统计学意义上的显著变化，IL-4 --经过 2 和 4 周的应激负荷后发生了显著变化。在慢性应激的第 2 周，大鼠体内 C3 成分的裂解百分比逐渐增加，但随后又有所下降，到研究结束时与对照组（完整动物）的数值几乎没有差异。这些结果说明了补体系统 C 组份指标变化的特异性，以及血液中细胞因子谱的变化，反映了大鼠在反复暴露于不同来源和持续时间的应激因素时免疫反应的细胞和体液组份的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.