Biomolecular condensates with liquid properties formed during viral infections.

IF 2.6 4区 医学 Q3 IMMUNOLOGY Microbes and Infection Pub Date : 2024-08-08 DOI:10.1016/j.micinf.2024.105402
Damien Glon, Benjamin Léonardon, Ariane Guillemot, Aurélie Albertini, Cécile Lagaudrière-Gesbert, Yves Gaudin
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Abstract

During a viral infection, several membraneless compartments with liquid properties are formed. They can be of viral origin concentrating viral proteins and nucleic acids, and harboring essential stages of the viral cycle, or of cellular origin containing components involved in innate immunity. This is a paradigm shift in our understanding of viral replication and the interaction between viruses and innate cellular immunity.

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病毒感染过程中形成的具有液体特性的生物分子凝聚物。
在病毒感染过程中,会形成几个具有液体特性的无膜区。它们可能来自病毒,集中了病毒蛋白质和核酸,并包含病毒循环的重要阶段;也可能来自细胞,包含参与先天免疫的成分。这是我们对病毒复制以及病毒与先天性细胞免疫之间相互作用的认识的一次范式转变。
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来源期刊
Microbes and Infection
Microbes and Infection 医学-病毒学
CiteScore
12.60
自引率
1.70%
发文量
90
审稿时长
40 days
期刊介绍: Microbes and Infection publishes 10 peer-reviewed issues per year in all fields of infection and immunity, covering the different levels of host-microbe interactions, and in particular: the molecular biology and cell biology of the crosstalk between hosts (human and model organisms) and microbes (viruses, bacteria, parasites and fungi), including molecular virulence and evasion mechanisms. the immune response to infection, including pathogenesis and host susceptibility. emerging human infectious diseases. systems immunology. molecular epidemiology/genetics of host pathogen interactions. microbiota and host "interactions". vaccine development, including novel strategies and adjuvants. Clinical studies, accounts of clinical trials and biomarker studies in infectious diseases are within the scope of the journal. Microbes and Infection publishes articles on human pathogens or pathogens of model systems. However, articles on other microbes can be published if they contribute to our understanding of basic mechanisms of host-pathogen interactions. Purely descriptive and preliminary studies are discouraged.
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