Influence of Age, Gender and Body Mass Index on Intravenous Pharmacokinetics of Buprenorphine in Children Undergoing Orthopedic Surgery.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-08-08 eCollection Date: 2024-07-01 DOI:10.1177/15593258241266469

Liliana Rivera-Espinosa, Eréndira Vicencio-Rosas, Carmen Flores-Pérez, Janett Flores-Pérez, Ismael Lares-Asseff, Jesús Alonso Gándara Mireles, Edelmira Solorio-López, Juan Luis Chávez-Pacheco

{"title":"Influence of Age, Gender and Body Mass Index on Intravenous Pharmacokinetics of Buprenorphine in Children Undergoing Orthopedic Surgery.","authors":"Liliana Rivera-Espinosa, Eréndira Vicencio-Rosas, Carmen Flores-Pérez, Janett Flores-Pérez, Ismael Lares-Asseff, Jesús Alonso Gándara Mireles, Edelmira Solorio-López, Juan Luis Chávez-Pacheco","doi":"10.1177/15593258241266469","DOIUrl":null,"url":null,"abstract":"Background: Buprenorphine (BPN) is a widely used analgesic in the pediatric population, although there are few studies on the pharmacokinetics and pharmacodynamics of this drug.Objective: The objective was to characterize the pharmacokinetics of BPN after intravenous administration and analyze the effect of age, gender, weight, height, body mass index (BMI), and drug-drug interactions as covariates.Methods: Ninety-nine children (2-10 years), who underwent orthopedic surgery under regional, general, or combined anesthesia were included. Patients evaluated according to the American Society of Anesthesiologists Physical Status Classification, who received intravenous BPN 2 μg/kg were enrolled. Blood was collected from 1-240 min. Drug plasma concentrations were determined by LC-MS/MS. Population pharmacokinetic parameters were obtained with Monolix 2021R1 software. Pearson's correlation and/or ANOVA were used for statistical analysis.Results: Age was associated with changes in clearance and central compartment volume and the female gender was associated with lower intercompartmental clearance, while BMI modified clearance, central and peripheral compartment volume. Concomitant administration of BPN with fentanyl and dexamethasone produced decreases in clearance.Conclusions: The covariates of sex, age, and BMI are directly related to the increase or decrease in BPN pharmacokinetic parameters.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311171/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15593258241266469","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Buprenorphine (BPN) is a widely used analgesic in the pediatric population, although there are few studies on the pharmacokinetics and pharmacodynamics of this drug.

Objective: The objective was to characterize the pharmacokinetics of BPN after intravenous administration and analyze the effect of age, gender, weight, height, body mass index (BMI), and drug-drug interactions as covariates.

Methods: Ninety-nine children (2-10 years), who underwent orthopedic surgery under regional, general, or combined anesthesia were included. Patients evaluated according to the American Society of Anesthesiologists Physical Status Classification, who received intravenous BPN 2 μg/kg were enrolled. Blood was collected from 1-240 min. Drug plasma concentrations were determined by LC-MS/MS. Population pharmacokinetic parameters were obtained with Monolix 2021R1 software. Pearson's correlation and/or ANOVA were used for statistical analysis.

Results: Age was associated with changes in clearance and central compartment volume and the female gender was associated with lower intercompartmental clearance, while BMI modified clearance, central and peripheral compartment volume. Concomitant administration of BPN with fentanyl and dexamethasone produced decreases in clearance.

Conclusions: The covariates of sex, age, and BMI are directly related to the increase or decrease in BPN pharmacokinetic parameters.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

年龄、性别和体重指数对接受矫形手术儿童丁丙诺啡静脉注射药代动力学的影响

背景：丁丙诺啡（BPN）是一种广泛用于儿童的镇痛药，但有关该药的药代动力学和药效学研究却很少：目的：研究 BPN 静脉给药后的药代动力学特征，并分析年龄、性别、体重、身高、体重指数（BMI）和药物间相互作用作为协变量的影响：纳入在区域麻醉、全身麻醉或复合麻醉下接受骨科手术的 99 名儿童（2-10 岁）。根据美国麻醉医师协会身体状况分类进行评估，并接受 2 μg/kg BPN 静脉注射的患者为研究对象。血液采集时间为 1-240 分钟。通过 LC-MS/MS 测定药物血浆浓度。使用 Monolix 2021R1 软件获得群体药代动力学参数。采用皮尔逊相关性和/或方差分析进行统计分析：结果：年龄与清除率和中心室容积的变化有关，女性与较低的室间清除率有关，而体重指数会改变清除率、中心室和外周室容积。同时服用 BPN 与芬太尼和地塞米松会导致清除率下降：结论：性别、年龄和体重指数等协变量与 BPN 药代动力学参数的增减直接相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊