{"title":"Copper-catalyzed oxidative intramolecular cyclization for the synthesis of 2-hydroxy-indolin-3-ones","authors":"Haojie Ma, Fengyuan Zhou, Yuqi Li, Yuqi Zhang, Guosheng Huang, Xing Yang, Ji-Jiang Wang","doi":"10.1002/adsc.202400493","DOIUrl":null,"url":null,"abstract":"The synthesis of substituted 2-hydroxy-indolin-3-ones has attracted considerable attention due to the frequent presence of the indole nucleus in numerous natural products and biologically active molecules. Herein, a direct access to 2-hydroxy-indolin-3-ones through copper-catalyzed oxidative intramolecular cyclization of N-(2-acetylphenyl)picolinamide has been developed. This method exhibits good functional group tolerance, atom-economy and avoids the pre-functionalization of substrates.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202400493","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The synthesis of substituted 2-hydroxy-indolin-3-ones has attracted considerable attention due to the frequent presence of the indole nucleus in numerous natural products and biologically active molecules. Herein, a direct access to 2-hydroxy-indolin-3-ones through copper-catalyzed oxidative intramolecular cyclization of N-(2-acetylphenyl)picolinamide has been developed. This method exhibits good functional group tolerance, atom-economy and avoids the pre-functionalization of substrates.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
