Anna Vesty, Xiaoyun Ren, Prachi Sharma, Natalie Lorenz, T. Proft, Allan Hardaker, Christina Straub, J. Morgan, Audrey Tiong, Anneka Anderson, Rachel H Webb, Julie Bennett, Philip E Carter, N. Moreland
{"title":"The emergence and impact of the M1UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand","authors":"Anna Vesty, Xiaoyun Ren, Prachi Sharma, Natalie Lorenz, T. Proft, Allan Hardaker, Christina Straub, J. Morgan, Audrey Tiong, Anneka Anderson, Rachel H Webb, Julie Bennett, Philip E Carter, N. Moreland","doi":"10.1093/ofid/ofae457","DOIUrl":null,"url":null,"abstract":"\n M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen SpeA. We show M1UK is now the dominant invasive emm1 lineage in New Zealand and is genomically related to community infections, suggesting measures that effectively prevent GAS-pharyngitis in children could reduce invasive disease.","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofae457","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen SpeA. We show M1UK is now the dominant invasive emm1 lineage in New Zealand and is genomically related to community infections, suggesting measures that effectively prevent GAS-pharyngitis in children could reduce invasive disease.
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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