Sex-Specific Differences in Kidney Function and Blood Pressure Regulation

IF 5.5 3区 材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-08-08 DOI:10.3390/ijms25168637
Eleni Stamellou, Viktor Sterzer, Jessica Alam, Stefanos Roumeliotis, Vasillios Liakopoulos, E. Dounousi
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Abstract

Premenopausal women generally exhibit lower blood pressure and a lower prevalence of hypertension than men of the same age, but these differences reverse postmenopause due to estrogen withdrawal. Sexual dimorphism has been described in different components of kidney physiology and pathophysiology, including the renin–angiotensin–aldosterone system, endothelin system, and tubular transporters. This review explores the sex-specific differences in kidney function and blood pressure regulation. Understanding these differences provides insights into potential therapeutic targets for managing hypertension and kidney diseases, considering the patient’s sex and hormonal status.
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肾功能和血压调节的性别差异
与同龄男性相比,绝经前女性的血压通常较低,高血压发病率也较低,但绝经后由于雌激素的减少,这些差异会逆转。肾脏生理和病理生理学的不同组成部分,包括肾素-血管紧张素-醛固酮系统、内皮素系统和肾小管转运体,都存在性别双态性。本综述探讨了肾功能和血压调节方面的性别差异。通过了解这些差异,我们可以深入了解管理高血压和肾脏疾病的潜在治疗目标,同时考虑到患者的性别和荷尔蒙状态。
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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