Copper iodine cluster nanoparticles for tumor-targeted X-ray-induced photodynamic therapy

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Science China Materials Pub Date : 2024-08-06 DOI:10.1007/s40843-024-2958-1

Wei Xie (, ), Junyun Chen (, ), Yuxin Zhang (, ), Biyuan Zheng (, ), Xingshu Li (, ), Jian-Dong Huang (, )

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Abstract

The weakness of visible and near-infrared light penetration depth limits the application of photodynamic therapy (PDT) in deep-seated tumors. Based on the high penetrability of X-rays, X-ray-induced PDT (X-PDT) is a promising new method for treating deep-seated tumors. However, it requires the development of suitable X-ray-induced sensitizers that could employ X-ray energy to produce reactive oxygen species (ROS) efficiently. In this study, a novel X-ray-induced sensitizer (NanoSRF) was developed through a microemulsion method, in which copper iodine cluster compound Cu₂I₂(tpp)₂(2,5-dm-pz) (CIP) and rose bengal (RB) worked as scintillator and photosensitizer, respectively. CIP was synthesized by a simple mechanical grinding method, and subsequently folic acid (FA)-modified albumin was introduced to enable its alliance with RB. NanoSRF exhibited excellent dispersion stability and generated a large amount of ROS under X-ray irradiation. The results of in vitro studies demonstrated its high selectivity for FA receptor-positive cancer cells. Following systemic administration, NanoSRF accumulated in H22 tumors of xenograft-bearing mice, and X-ray irradiation (5.46 Gy) induced a significant inhibition rate of 96.7% in tumor growth. This study pioneers the use of copper iodide cluster as a scintillator in X-PDT, presenting new possibilities for designing scintillators with exceptional X-ray absorption and efficient X-PDT capabilities.

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用于肿瘤靶向 X 射线诱导光动力疗法的碘簇纳米铜粒子

可见光和近红外线的穿透深度较弱，这限制了光动力疗法（PDT）在深部肿瘤中的应用。基于 X 射线的高穿透性，X 射线诱导的光动力疗法（X-PDT）是治疗深部肿瘤的一种前景广阔的新方法。然而，这需要开发合适的 X 射线诱导敏化剂，利用 X 射线能量有效地产生活性氧（ROS）。本研究通过微乳液法开发了一种新型 X 射线诱导敏化剂（NanoSRF），其中碘铜簇化合物 Cu2I2(tpp)2(2,5-dm-pz) (CIP) 和玫瑰红 (RB) 分别用作闪烁体和光敏剂。CIP 是通过简单的机械研磨方法合成的，随后引入了叶酸（FA）修饰的白蛋白，使其能够与 RB 结合。NanoSRF 具有出色的分散稳定性，并能在 X 射线照射下产生大量 ROS。体外研究结果表明，它对 FA 受体阳性的癌细胞具有高度选择性。全身给药后，NanoSRF 在异种移植小鼠的 H22 肿瘤中积累，X 射线照射（5.46 Gy）对肿瘤生长的抑制率高达 96.7%。这项研究开创了将碘化铜簇作为闪烁体用于 X-PDT 的先河，为设计具有优异 X 射线吸收能力和高效 X-PDT 功能的闪烁体提供了新的可能性。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.