{"title":"Palladium-catalyzed cyclization borylmethylation: Access to boryl-functionalized benzene-fused heterocycle compounds","authors":"","doi":"10.1016/j.tetlet.2024.155216","DOIUrl":null,"url":null,"abstract":"<div><p>A palladium-catalyzed intramolecular cyclization borylmethylation of alkene-tethered aryl iodide with 1,1-diborylmethane has been described. This method offers an efficient route to synthesize various benzo-heterocyclic compounds containing oxygen or nitrogen atoms. Further experiments have demonstrated that the products can be employed to synthesize a series of potentially biological active heterocyclic compounds.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003113","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A palladium-catalyzed intramolecular cyclization borylmethylation of alkene-tethered aryl iodide with 1,1-diborylmethane has been described. This method offers an efficient route to synthesize various benzo-heterocyclic compounds containing oxygen or nitrogen atoms. Further experiments have demonstrated that the products can be employed to synthesize a series of potentially biological active heterocyclic compounds.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.