{"title":"Oncogenomics in the classification of mature B-and T-cell lymphomas: where are we now?","authors":"Satyen Gohil, Sabine Pomplun","doi":"10.1016/j.mpdhp.2024.05.005","DOIUrl":null,"url":null,"abstract":"<div><p>Our understanding of the molecular aberrations in lymphoma, has been revolutionized by large scale sequencing studies, which has identified genetic mutations, transcriptional states and epigenetic dysregulation that define key subtypes with distinct biological properties and outcomes. Herein we provide an introduction to these findings, with a focus on mature B and T cell neoplasms, and discuss their significance in this vast and immensely fast moving field.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 8","pages":"Pages 457-465"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Histopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S175623172400080X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Our understanding of the molecular aberrations in lymphoma, has been revolutionized by large scale sequencing studies, which has identified genetic mutations, transcriptional states and epigenetic dysregulation that define key subtypes with distinct biological properties and outcomes. Herein we provide an introduction to these findings, with a focus on mature B and T cell neoplasms, and discuss their significance in this vast and immensely fast moving field.
期刊介绍：
This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.
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