{"title":"A new split-ring protoilludane-type sesquiterpenoid and prenylated aromatic compounds from Coriolopsis trogii","authors":"Xin-Meng Zhai, Lu-Lu Wang, Ning Li, Fu-Cai Ren","doi":"10.1016/j.phytol.2024.07.008","DOIUrl":null,"url":null,"abstract":"<div><p>One hitherto unknown protoilludane-type sesquiterpene, 8<em>β</em>-hydroxyepicoterpene D (<strong>1</strong>), along with two novel prenylated aromatic compounds, namely coriolopsisins A and B (<strong>2</strong>–<strong>3</strong>), were isolated from the ethanol extract of <em>Coriolopsis trogii</em> fruit body. Their structures were determined through extensive spectroscopic data analysis and comparison of experimental and calculated electronic circular dichroism data. Compounds <strong>2</strong> and <strong>3</strong> are rare examples in which the isopentenyl group is attached to the side chain of the aromatic ring rather than directly to the aromatic ring, containing succinimide and alkynyl segments, respectively. Plausible biosynthetic pathways of compounds <strong>2</strong> and <strong>3</strong> are proposed and unique aromatic prenyltransferases may exist.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 8-13"},"PeriodicalIF":1.3000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001071","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
One hitherto unknown protoilludane-type sesquiterpene, 8β-hydroxyepicoterpene D (1), along with two novel prenylated aromatic compounds, namely coriolopsisins A and B (2–3), were isolated from the ethanol extract of Coriolopsis trogii fruit body. Their structures were determined through extensive spectroscopic data analysis and comparison of experimental and calculated electronic circular dichroism data. Compounds 2 and 3 are rare examples in which the isopentenyl group is attached to the side chain of the aromatic ring rather than directly to the aromatic ring, containing succinimide and alkynyl segments, respectively. Plausible biosynthetic pathways of compounds 2 and 3 are proposed and unique aromatic prenyltransferases may exist.
期刊介绍:
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.