Remnant cholesterol is more positively related to diabetes, prediabetes, and insulin resistance than conventional lipid parameters and lipid ratios: A multicenter, large sample survey

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-08-13 DOI:10.1111/1753-0407.13592

Binqi Li, Yang Liu, Xin Zhou, Lulu Chen, Li Yan, Xulei Tang, Zhengnan Gao, Qin Wan, Zuojie Luo, Guijun Qin, Guang Ning, Weijun Gu, Yiming Mu

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Abstract

Background

Not many large-sample investigations are available that compare the potency of the relationship of remnant cholesterol (RC) and other lipid parameters with diabetes and prediabetes. The goals of our study are to discover the relationship between RC and prediabetes, diabetes, and insulin resistance (IR) and to investigate RC, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C, which are the lipid parameters that are most positively related to diabetes, prediabetes, and IR.

Methods

This research enrolled 36 684 subjects from China's eight provinces. We employed multiple logistic regression analysis for testing the relationship between lipid parameters and diabetes, prediabetes, and IR.

Results

After adjusting for potential confounders, and comparing the results with other lipid parameters, the positive relationship between RC and diabetes (odds ratio [OR] 1.417, 95% confidence interval [CI]: 1.345–1.492), prediabetes (OR 1.555, 95% CI: 1.438–1.628), and IR (OR 1.488, 95% CI: 1.404–1.577) was highest. RC was still related to diabetes, prediabetes, and IR even when TG <2.3 mmol/L (diabetes: OR 1.256, 95% CI: 1.135–1.390; prediabetes: OR 1.503, 95% CI: 1.342–1.684; and IR: OR 1.278, 95% CI: 1.140–1.433), LDL-C <2.6 mmol/L (diabetes: OR 1.306, 95% CI: 1.203–1.418; prediabetes: OR 1.597, 95% CI: 1.418–1.798; and IR: OR 1.552, 95% CI: 1.416–1.701), or HDL-C ≥1 mmol/L (diabetes: OR 1.456, 95% CI: 1.366–1.550; prediabetes: OR 1.553, 95% CI: 1.421–1.697; and IR: OR 1.490, 95% CI: 1.389–1.598).

Conclusion

RC is more positively related to diabetes, prediabetes, and IR than conventional lipids and lipid ratios in the general population, the relationships between RC and diabetes, prediabetes, and IR are stable, even if HDL-C, LDL-C, or TG are at appropriate levels.

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残余胆固醇与糖尿病、糖尿病前期和胰岛素抵抗的正相关性高于常规血脂参数和血脂比率：一项多中心、大样本调查。

背景：将残余胆固醇（RC）和其他血脂参数与糖尿病和糖尿病前期的关系进行比较的大样本调查并不多。我们的研究目标是发现残余胆固醇与糖尿病前期、糖尿病和胰岛素抵抗（IR）之间的关系，并研究与糖尿病、糖尿病前期和IR呈正相关的血脂指标--残余胆固醇、高密度脂蛋白胆固醇（HDL-C）、非高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、TC/HDL-C、LDL-C/HDL-C和TG/HDL-C：本研究从中国 8 个省招募了 36 684 名受试者。我们采用多元逻辑回归分析法检验血脂指标与糖尿病、糖尿病前期和红外之间的关系：在调整了潜在的混杂因素并与其他血脂参数进行比较后，RC 与糖尿病（几率比[OR] 1.417，95% 置信区间[CI]：1.345-1.492）、糖尿病前期（OR 1.555，95% 置信区间：1.438-1.628）和 IR（OR 1.488，95% 置信区间：1.404-1.577）的正相关性最高。即使得出 TG 结论，RC 仍与糖尿病、糖尿病前期和 IR 相关：与普通人群中的传统血脂和血脂比率相比，RC 与糖尿病、糖尿病前期和 IR 的正相关性更高，即使高密度脂蛋白胆固醇、低密度脂蛋白胆固醇或总胆固醇处于适当水平，RC 与糖尿病、糖尿病前期和 IR 的关系也是稳定的。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.