Resident memory T cells and cancer

IF 25.5 1区 医学 Q1 IMMUNOLOGY Immunity Pub Date : 2024-08-13 DOI:10.1016/j.immuni.2024.06.017
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引用次数: 0

Abstract

Tissue-resident memory T (TRM) cells positively correlate with cancer survival, but the anti-tumor mechanisms underlying this relationship are not understood. This review reconciles these observations, summarizing concepts of T cell immunosurveillance, fundamental TRM cell biology, and clinical observations on the role of TRM cells in cancer and immunotherapy outcomes. We also discuss emerging strategies that utilize TRM-phenotype cells for patient diagnostics, staging, and therapy. Current challenges are highlighted, including a lack of standardized T cell nomenclature and our limited understanding of relationships between T cell markers and underlying tumor biology. Existing findings are integrated into a summary of the field while emphasizing opportunities for future research.

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驻留记忆 T 细胞与癌症
组织驻留记忆 T(TRM)细胞与癌症存活率呈正相关,但这种关系的抗肿瘤机制尚不清楚。本综述调和了这些观察结果,总结了 T 细胞免疫监视的概念、TRM 细胞的基本生物学特性以及有关 TRM 细胞在癌症和免疫治疗结果中作用的临床观察结果。我们还讨论了利用TRM表型细胞进行患者诊断、分期和治疗的新兴策略。我们强调了当前面临的挑战,包括缺乏标准化的 T 细胞命名法,以及我们对 T 细胞标记物与潜在肿瘤生物学之间关系的了解有限。在强调未来研究机遇的同时,还将现有研究成果纳入该领域的总结中。
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来源期刊
Immunity
Immunity 医学-免疫学
CiteScore
49.40
自引率
2.20%
发文量
205
审稿时长
6 months
期刊介绍: Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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