Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights.

IF 6.3 1区 医学 Q1 DERMATOLOGY Burns & Trauma Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI:10.1093/burnst/tkae021
Arshia Fakouri, Zahra-Sadat Razavi, Adil Tawfeeq Mohammed, Abbas Hameed Abdul Hussein, Hamed Afkhami, Mohammad Hosseini Hooshiar
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Abstract

The healing process at a wound is made up of many types of cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex and changing ways. Microbial colonization and proliferation are possible at the place of injury, which makes infection more likely. Because of this, any cut has a chance of getting an infection. Researchers have found that wound infections make patients more upset and cost the healthcare system a lot of money. Surgical site infections happen a lot to people who have recently had surgery. This study shows that such surgical infection is linked to a high rate of illness and death. This is shown by the fact that 25% of patients get serious sepsis and need to be transferred to an intensive care unit. In both animal models and people, mesenchymal stem cells (MSCs) play an active role in all stages of wound healing and have positive effects. Exosomes are one of the main things MSCs release. They have effects that are similar to those of the parent MSCs. Various effector proteins, messenger RNA and microRNAs can be transported by extracellular vesicles to control the activity of target cells. This has a big impact on the healing process. These results suggest that using MSC-exosomes as a new type of cell-free therapy could be a better and safer option than whole cell therapy. This review is mostly about how to use parts of MSC-exosomes to help wound infections heal.

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间充质干细胞外泌体成分在伤口感染愈合中的应用:新见解。
伤口的愈合过程是由多种类型的细胞、生长因子、细胞外基质、神经和血管以复杂多变的方式相互作用组成的。受伤处可能会有微生物定植和增殖,这就增加了感染的可能性。因此,任何伤口都有感染的可能。研究人员发现,伤口感染会让病人更加难过,也会让医疗系统花费大量金钱。手术部位感染经常发生在刚做完手术的人身上。这项研究表明,这种手术感染与高患病率和高死亡率有关。25%的患者会患上严重的败血症,需要转入重症监护室,这就说明了这一点。在动物模型和人体中,间充质干细胞(MSCs)在伤口愈合的各个阶段都发挥着积极作用,并产生积极影响。外泌体是间充质干细胞释放的主要物质之一。它们具有与母体间充质干细胞相似的作用。各种效应蛋白、信使核糖核酸和微核糖核酸可通过细胞外囊泡运输,从而控制靶细胞的活性。这对愈合过程有很大影响。这些结果表明,使用间充质干细胞外泌体作为一种新型的无细胞疗法,可能是比全细胞疗法更好、更安全的选择。这篇综述主要介绍了如何利用间充质干细胞外泌体的一部分来帮助伤口感染愈合。
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来源期刊
Burns & Trauma
Burns & Trauma 医学-皮肤病学
CiteScore
8.40
自引率
9.40%
发文量
186
审稿时长
6 weeks
期刊介绍: The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.
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