Meta-analysis of the correlation between high expression of lncRNA NEAT1 in rectal cancer and pathological features and prognosis.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2024-06-15 DOI:10.5937/jomb0-47889

Qiyi Lin, Jianpeng Pan, Huaishuai Wang, Yinlin Li, Yixiang Zhuang, Zhicong Cai, Gaofeng Lin, Weibo Liu, Guoxi Xu

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Abstract

Background: To systematically evaluate the relationship between the expression level of long noncoding RNA NEAT1 and the clinical characteristics and prognostic value of rectal cancer patients.

Methods: PubMed, EMBASE, Cochrane library database and case-control studies on the correlation between abnormal expression of lncRNA NEAT1 and prognosis of rectal cancer patients published by the American clinical trials registry before May 1, 2023 were searched. The search time was from the establishment of the database to May 30, 2023.

Results: A total of 7 case-control studies were included, including 1063 cancer patients. The results of meta-analysis showed that the high expression of lncRNA NEAT1 was significantly correlated with the degree of differentiation [or=0.45, 95%CI=0.32-0.63, P<0.01], tumor size [or=0.59, 95%CI=0.42-0.82, P<0.01], and overall survival [HR=1.34, 95%CI=1.21-1.48, P<0.001]; However, it was not associated with gender [or=1.23, 95%CI= 0.88-1.72, P=0.23] and lymph node metastasis [or=0.87, 95%CI=0.45-1.66, P=0.67].

Conclusions: The high expression of lncRNA NEAT1 may be a risk factor for poor prognosis in patients with malignant tumors, and lncRNA NEAT1 can be used as a potential biomarker to evaluate its prognosis.

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直肠癌中 lncRNA NEAT1 高表达与病理特征和预后相关性的 Meta 分析

背景：系统评估长非编码RNA NEAT1的表达水平与直肠癌患者临床特征和预后价值之间的关系：目的：系统评估长非编码RNA NEAT1的表达水平与直肠癌患者临床特征和预后价值之间的关系：方法：检索PubMed、EMBASE、Cochrane图书馆数据库以及美国临床试验注册中心在2023年5月1日之前发表的关于lncRNA NEAT1异常表达与直肠癌患者预后相关性的病例对照研究。检索时间为数据库建立至2023年5月30日：结果：共纳入7项病例对照研究，包括1063名癌症患者。荟萃分析结果显示，lncRNA NEAT1的高表达与分化程度显著相关[或=0.45，95%CI=0.32-0.63，PConclusions：lncRNA NEAT1的高表达可能是恶性肿瘤患者预后不良的危险因素，lncRNA NEAT1可作为潜在的生物标志物来评估其预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.