Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer

IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Breast Journal Pub Date : 2024-08-12 DOI:10.1155/2024/3461694
Negar Soltani Irdmusa, Haniyeh Bashi Zadeh Fakhar, Masoumeh Heshmati, Mohammad Esmaiel Akbari, Sara Rahimi
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Abstract

Breast cancer (BC), a globally prevalent malignancy, shows significant variability in incidence across different geographical regions. In this study, we examined the expression of the tumor suppressor gene BRCA1 and the tumor marker CA15-3 in women diagnosed with BC, focusing on different cancer grades. Our research, conducted at the Baqiyat Elah Hospital in Tehran in 2021, involved collecting blood and serum samples from BC patients. These samples underwent BRCA1 gene expression analysis and CA15-3 tumor marker assessment. Using the AJCC grading system, we categorized BC patients into various grades. Our findings revealed that BRCA1 gene expression was present in 28.57% of patients, while 71.43% showed negative expression. Both BRCA1 expression and CA15-3 levels significantly increased with advanced cancer stages (P < 0.001). These results suggest the potential utility of BRCA1 gene expression and CA15-3 tumor marker assessment in BC prognosis and management, particularly concerning staging and disease progression. This study provides valuable insights into the biology of BC and the development of prognostic markers for improved patient outcomes.

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不同分期乳腺癌中 BRCA1 基因表达与 CA15-3 肿瘤标志物水平的比较
乳腺癌(BC)是一种全球流行的恶性肿瘤,不同地理区域的发病率差异很大。在这项研究中,我们检测了确诊为乳腺癌的妇女体内肿瘤抑制基因 BRCA1 和肿瘤标志物 CA15-3 的表达情况,重点关注不同癌症等级。我们的研究于 2021 年在德黑兰的 Baqiyat Elah 医院进行,收集了 BC 患者的血液和血清样本。对这些样本进行了 BRCA1 基因表达分析和 CA15-3 肿瘤标志物评估。根据 AJCC 分级系统,我们将 BC 患者分为不同等级。我们的研究结果显示,28.57%的患者存在 BRCA1 基因表达,71.43%的患者呈阴性表达。BRCA1 表达和 CA15-3 水平均随癌症晚期而明显升高(P < 0.001)。这些结果表明,BRCA1基因表达和CA15-3肿瘤标志物评估在BC预后和管理中具有潜在的实用性,尤其是在分期和疾病进展方面。这项研究为了解 BC 的生物学特性和开发预后标志物以改善患者预后提供了宝贵的见解。
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来源期刊
Breast Journal
Breast Journal 医学-妇产科学
CiteScore
4.00
自引率
0.00%
发文量
47
审稿时长
4-8 weeks
期刊介绍: The Breast Journal is the first comprehensive, multidisciplinary source devoted exclusively to all facets of research, diagnosis, and treatment of breast disease. The Breast Journal encompasses the latest news and technologies from the many medical specialties concerned with breast disease care in order to address the disease within the context of an integrated breast health care. This editorial philosophy recognizes the special social, sexual, and psychological considerations that distinguish cancer, and breast cancer in particular, from other serious diseases. Topics specifically within the scope of The Breast Journal include: Risk Factors Prevention Early Detection Diagnosis and Therapy Psychological Issues Quality of Life Biology of Breast Cancer.
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