Recent advances of 3-fucosyllactose in health effects and production

IF 2.6 3区 生物学 Q3 MICROBIOLOGY Archives of Microbiology Pub Date : 2024-08-14 DOI:10.1007/s00203-024-04104-2
Zhihui Du, Zeyu Li, Cuie Guang, Yingying Zhu, Wanmeng Mu
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Abstract

Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2′-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.

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3-岩藻糖在健康影响和生产方面的最新进展。
人乳低聚糖(HMOs)已被公认为婴儿发育的黄金标准。作为公认安全的人乳寡糖之一,3-岩藻糖(3-FL)是人乳寡糖领域的核心三糖;然而,与研究广泛的 2'-岩藻糖相比,它受到的关注相对较少。本综述旨在全面总结 3-FL 对健康的影响,包括对肠道微生物群增殖、抗菌作用、免疫调节、抗病毒保护和大脑成熟的影响。此外,还讨论了 3-FL 的商业应用和监管审批情况。最后,对 3-FL 的大规模生产方法进行了有条理的介绍,旨在提供一份全面的指南,重点介绍当前的优化策略和面临的挑战。
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来源期刊
Archives of Microbiology
Archives of Microbiology 生物-微生物学
CiteScore
4.90
自引率
3.60%
发文量
601
审稿时长
3 months
期刊介绍: Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.
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