Getting smart – Deciphering the neuronal functions of protein kinase D

IF 4.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Molecular cell research Pub Date : 2024-08-14 DOI:10.1016/j.bbamcr.2024.119812

Katalin Schlett , Carlos O. Oueslati Morales , Norbert Bencsik , Angelika Hausser

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Abstract

Protein kinase D (PKD) is a family of serine/threonine kinases that play important roles in various signalling pathways in cells, including neuronal cells. In the nervous system, PKD has been shown to be involved in learning and memory formation by regulating neurotransmitter release, neurite outgrowth and dendrite development, synapse formation and synaptic plasticity. In addition, PKD has been implicated in pain perception or neuroprotection during oxidative stress. Dysregulation of PKD expression and activity has been linked to several neurological disorders, including autism and epilepsy. In this review, we summarize the current knowledge on the function of the PKD family members in neuronal cells, including the spatial regulation of their downstream signalling pathways. We will further discuss the potential role of PKD in the pathogenesis of neurological disorders.

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聪明起来--破译蛋白激酶 D 的神经元功能。

蛋白激酶 D（PKD）是丝氨酸/苏氨酸激酶家族的一员，在细胞（包括神经细胞）的各种信号通路中发挥着重要作用。在神经系统中，PKD 通过调节神经递质释放、神经元突起和树突发育、突触形成和突触可塑性，参与学习和记忆的形成。此外，PKD 还与痛觉或氧化应激时的神经保护有关。PKD 表达和活性失调与自闭症和癫痫等多种神经系统疾病有关。在这篇综述中，我们将总结目前有关 PKD 家族成员在神经元细胞中功能的知识，包括其下游信号通路的空间调控。我们还将进一步讨论 PKD 在神经系统疾病发病机制中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.