Calpain: The regulatory point of cardiovascular and cerebrovascular diseases

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biomedicine & Pharmacotherapy Pub Date : 2024-08-18 DOI:10.1016/j.biopha.2024.117272

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Abstract

Calpain, a key member of the Calpain cysteine protease superfamily, performs limited protein hydrolysis in a calcium-dependent manner. Its activity is tightly regulated due to the potential for non-specific cleavage of various intracellular proteins upon aberrant activation. A thorough review of the literature from 2010 to 2023 reveals 121 references discussing cardiovascular and cerebrovascular diseases. Dysregulation of the Calpain system is associated with various pathological phenomena, including lipid metabolism disorders, inflammation, apoptosis, and excitotoxicity. Although recent studies have revealed the significant role of Calpain in cardiovascular and cerebrovascular diseases, the precise mechanisms remain incompletely understood. Exploring the potential of Calpain inhibition as a therapeutic approach for the treatment of cardiovascular and cerebrovascular diseases may emerge as a compelling area of interest for future calpain research.

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钙蛋白酶：心脑血管疾病的调节点。

钙蛋白酶（Calpain）是钙蛋白酶半胱氨酸蛋白酶超家族的重要成员，以钙依赖方式进行有限的蛋白质水解。由于钙蛋白酶在异常激活时有可能非特异性地裂解各种细胞内蛋白质，因此其活性受到严格调控。对 2010 年至 2023 年的文献进行全面回顾后发现，有 121 篇参考文献讨论了心脑血管疾病。钙蛋白酶系统失调与多种病理现象有关，包括脂质代谢紊乱、炎症、细胞凋亡和兴奋毒性。尽管最近的研究揭示了钙蛋白酶在心脑血管疾病中的重要作用，但对其确切机制的了解仍不全面。探索钙蛋白酶抑制作为治疗心脑血管疾病的一种治疗方法的潜力，可能会成为未来钙蛋白酶研究的一个引人注目的兴趣领域。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.