Teeshyo Bhattacharya, Mamta Kumari, Kulwinder Kaur, Santanu Kaity, Somasundaram Arumugam, Velayutham Ravichandiran and Subhadeep Roy
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引用次数: 0
Abstract
Breast cancer (BC) is the second deadliest cancer after lung cancer. Similar to all cancers, it is also driven by a 3D microenvironment. The extracellular matrix (ECM) is an essential component of the 3D tumor micro-environment, wherein it functions as a scaffold for cells and provides metabolic support. BC is characterized by alterations in the ECM. Various studies have attempted to mimic BC-specific ECMs using artificial materials, such as Matrigel. Nevertheless, research has proven that naturally derived decellularized extracellular matrices (dECMs) are superior in providing the essential in vivo-like cues needed to mimic a cancer-like environment. Developing in vitro 3-D BC models is not straightforward and requires extensive analysis of the data established by researchers. For the benefit of researchers, in this review, we have tried to highlight all developmental studies that have been conducted by various scientists so far. The analysis of the conclusions drawn from these studies is also discussed. The advantages and drawbacks of the decellularization methods employed for generating BC scaffolds will be covered, and the review will shed light on how dECM scaffolds help develop a BC environment. The later stages of the article will also focus on immunogenicity issues arising from decellularization and the origin of the tissue. Finally, this review will also discuss the biofabrication of matrices, which is the core part of the bioengineering process.
乳腺癌(BC)是仅次于肺癌的第二大致命癌症。与所有癌症类似,乳腺癌也是由三维微环境驱动的。细胞外基质(ECM)是三维肿瘤微环境的重要组成部分,可作为细胞的支架并提供代谢支持。BC 以 ECM 的改变为特征。各种研究都试图使用 Matrigel 等人工材料来模拟 BC 特异性 ECM。然而,研究证明,天然衍生的脱细胞细胞外基质(dECMs)在提供模拟类癌环境所需的基本活体线索方面更胜一筹。开发体外 3-D BC 模型并不简单,需要对研究人员建立的数据进行大量分析。为了研究人员的利益,在本综述中,我们试图重点介绍迄今为止不同科学家进行的所有发育研究。我们还讨论了对这些研究结论的分析。本综述还将介绍用于生成 BC 支架的脱细胞方法的优点和缺点,并阐明 dECM 支架如何帮助开发 BC 环境。文章的后半部分还将重点讨论脱细胞和组织来源引起的免疫原性问题。最后,本综述还将讨论基质的生物制造,这是生物工程过程的核心部分。
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices