Intraventricular Glioblastomas: A Systematic Review of Multimodal Treatment Strategies.

IF 0.9 4区 医学 Q3 SURGERY Annali italiani di chirurgia Pub Date : 2024-01-01 DOI:10.62713/aic.3529
Gianluca Scalia, Gianluca Ferini, Francesca Graziano, Salvatore Marrone, Eliana Giurato, Maria Grazia Galasso, Oday Atallah, Minaam Farooq, Massimo Furnari, Giuseppe Emmanuele Umana, Giovanni Federico Nicoletti
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Abstract

Aim: Intraventricular glioblastomas (IVGBMs) are rare tumors within the central nervous system characterized by unique challenges in diagnosis and management due to their location within the ventricular system. Despite their rarity, these tumors necessitate comprehensive study to refine diagnostic approaches and optimize therapeutic strategies.

Methods: A systematic review was conducted using PubMed, Scopus, Web of Science, and Google Scholar databases to identify relevant literature published up to January 2024. Inclusion criteria encompassed studies in English focusing on clinical characteristics, radiological features, pathology, and treatment of IVGBM. Data synthesis and analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results: Twenty-four articles met the inclusion criteria, comprising 47 patients with IVGBM. The median age was 47 years, with a male predominance (32 males, 15 females). Common symptoms included increased intracranial pressure and seizures. Tumors predominantly affected the lateral ventricles (body and trigone). Surgical resection (subtotal or gross total) was the primary treatment approach, with adjuvant therapies (radiotherapy, chemotherapy) administered postoperatively.

Conclusions: IVGBM present distinct diagnostic and therapeutic challenges due to their ventricular location. Current treatments primarily involve surgical resection followed by adjuvant therapies, though outcomes remain guarded. Further research is needed to enhance understanding and management of this rare glioblastoma subset.

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脑室内胶质母细胞瘤:多模式治疗策略的系统回顾。
目的:室管膜内胶质母细胞瘤(IVGBMs)是中枢神经系统中罕见的肿瘤,由于其位于脑室系统内,因此在诊断和治疗方面面临独特的挑战。尽管这些肿瘤非常罕见,但仍有必要对其进行全面研究,以完善诊断方法和优化治疗策略:方法:我们使用 PubMed、Scopus、Web of Science 和 Google Scholar 数据库进行了系统性综述,以确定截至 2024 年 1 月发表的相关文献。纳入标准包括以 IVGBM 的临床特征、放射学特征、病理学和治疗为重点的英文研究。数据综合与分析遵循《系统综述与元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analyses,PRISMA)指南:24篇文章符合纳入标准,包括47名IVGBM患者。中位年龄为 47 岁,男性占多数(32 名男性,15 名女性)。常见症状包括颅内压增高和癫痫发作。肿瘤主要累及侧脑室(体部和三叉神经)。手术切除(次全切除或全切)是主要的治疗方法,术后进行辅助治疗(放疗、化疗):IVGBM因其位于脑室而给诊断和治疗带来了独特的挑战。目前的治疗方法主要是手术切除,然后进行辅助治疗,但疗效仍有待观察。需要进一步开展研究,以加强对这种罕见胶质母细胞瘤亚群的了解和管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.90
自引率
12.50%
发文量
116
审稿时长
>12 weeks
期刊介绍: Annali Italiani di Chirurgia is a bimonthly journal and covers all aspects of surgery:elective, emergency and experimental surgery, as well as problems involving technology, teaching, organization and forensic medicine. The articles are published in Italian or English, though English is preferred because it facilitates the international diffusion of the journal (v.Guidelines for Authors and Norme per gli Autori). The articles published are divided into three main sections:editorials, original articles, and case reports and innovations.
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