From sweat to hope: The role of exercise-induced extracellular vesicles in cancer prevention and treatment

IF 15.5 1区 医学 Q1 CELL BIOLOGY Journal of Extracellular Vesicles Pub Date : 2024-08-25 DOI:10.1002/jev2.12500
Alicia Llorente, Agnese Brokāne, Agata Mlynska, Marju Puurand, Krizia Sagini, Signe Folkmane, Marit Hjorth, Beatriz Martin-Gracia, Silvana Romero, Diana Skorinkina, Mārtiņš Čampa, Rūdolfs Cešeiko, Nadezhda Romanchikova, Aija Kļaviņa, Tuuli Käämbre, Aija Linē
{"title":"From sweat to hope: The role of exercise-induced extracellular vesicles in cancer prevention and treatment","authors":"Alicia Llorente,&nbsp;Agnese Brokāne,&nbsp;Agata Mlynska,&nbsp;Marju Puurand,&nbsp;Krizia Sagini,&nbsp;Signe Folkmane,&nbsp;Marit Hjorth,&nbsp;Beatriz Martin-Gracia,&nbsp;Silvana Romero,&nbsp;Diana Skorinkina,&nbsp;Mārtiņš Čampa,&nbsp;Rūdolfs Cešeiko,&nbsp;Nadezhda Romanchikova,&nbsp;Aija Kļaviņa,&nbsp;Tuuli Käämbre,&nbsp;Aija Linē","doi":"10.1002/jev2.12500","DOIUrl":null,"url":null,"abstract":"<p>The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":null,"pages":null},"PeriodicalIF":15.5000,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12500","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Extracellular Vesicles","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jev2.12500","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
从汗水到希望:运动诱导的细胞外囊泡在癌症预防和治疗中的作用。
经常进行体育锻炼对预防癌症、减轻疲劳、减少治疗副作用和复发、提高癌症患者的生活质量和总体生存率等方面的益处日益得到认可。初步研究表明,在体育锻炼过程中,细胞外囊泡 (EV) 的浓度会增加,而且 EV 会携带具有生物活性的货物。血细胞、骨骼肌和其他参与运动的器官都会释放这些囊泡,这表明囊泡可能会在运动过程中介导组织串联。这种可能性引发了人们对研究 EVs 在运动的全身适应中的作用及其在预防和治疗包括癌症在内的各种疾病中的潜在应用的极大兴趣。本综述介绍了有关运动过程中释放的 EVs 的浓度和分子载体的研究。此外,我们还讨论了可能引发不同类型细胞释放 EV 的假定刺激因素、生物功能以及运动诱导的 EV 对癌症发生和发展的影响。了解运动、EVs 和癌症生物学之间的相互作用可为新型癌症治疗策略和预防措施提供见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
27.30
自引率
4.40%
发文量
115
审稿时长
12 weeks
期刊介绍: The Journal of Extracellular Vesicles is an open access research publication that focuses on extracellular vesicles, including microvesicles, exosomes, ectosomes, and apoptotic bodies. It serves as the official journal of the International Society for Extracellular Vesicles and aims to facilitate the exchange of data, ideas, and information pertaining to the chemistry, biology, and applications of extracellular vesicles. The journal covers various aspects such as the cellular and molecular mechanisms of extracellular vesicles biogenesis, technological advancements in their isolation, quantification, and characterization, the role and function of extracellular vesicles in biology, stem cell-derived extracellular vesicles and their biology, as well as the application of extracellular vesicles for pharmacological, immunological, or genetic therapies. The Journal of Extracellular Vesicles is widely recognized and indexed by numerous services, including Biological Abstracts, BIOSIS Previews, Chemical Abstracts Service (CAS), Current Contents/Life Sciences, Directory of Open Access Journals (DOAJ), Journal Citation Reports/Science Edition, Google Scholar, ProQuest Natural Science Collection, ProQuest SciTech Collection, SciTech Premium Collection, PubMed Central/PubMed, Science Citation Index Expanded, ScienceOpen, and Scopus.
期刊最新文献
A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer Correction to MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti-tumour immunity A novel multiplexed immunoassay for surface-exposed proteins in plasma extracellular vesicles Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer's disease Real-time monitoring of small extracellular vesicles (sEVs) by in vivo flow cytometry
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1