Associations between accelerometer-derived sedentary behavior and physical activity with white matter hyperintensities in middle-aged to older adults.

IF 4 Q1 CLINICAL NEUROLOGY Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-08-23 eCollection Date: 2024-07-01 DOI:10.1002/dad2.70001

David A Raichlen, Madeline Ally, Daniel H Aslan, M Katherine Sayre, Pradyumna K Bharadwaj, Silvio Maltagliati, Mark H C Lai, Rand R Wilcox, Christian G Habeck, Yann C Klimentidis, Gene E Alexander

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引用次数: 0

Abstract

Introduction: We examined the relationship between sedentary behavior (SB), moderate-to-vigorous physical activity (MVPA), and white matter hyperintensity (WMH) volumes, a common magnetic resonance imaging (MRI) marker associated with risk of neurodegenerative disease in middle-aged to older adults.

Methods: We used data from the UK Biobank (n = 14,415; 45 to 81 years) that included accelerometer-derived measures of SB and MVPA, and WMH volumes from MRI.

Results: Both MVPA and SB were associated with WMH volumes (β_MVPA= -0.03 [-0.04, -0.01], p < 0.001; β_SB= 0.02 [0.01, 0.03], p = 0.007). There was a significant interaction between SB and MVPA on WMH volumes (β_SB×MVPA= -0.015 [-0.028, -0.001], p _SB×MVPA = 0.03) where SB was positively associated with WMHs at low MVPA, and MVPA was negatively associated with WMHs at high SB.

Discussion: While this study cannot establish causality, the results highlight the potential importance of considering both MVPA and SB in strategies aimed at reducing the accumulation of WMH volumes in middle-aged to older adults.

Highlights: SB is associated with greater WMH volumes and MVPA is associated with lower WMH volumes.Relationships between SB and WMH are strongest at low levels of MVPA.Associations between MVPA and WMH are strongest at high levels of SB.Considering both SB and MVPA may be effective strategies for reducing WMHs.

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加速度计得出的中老年人久坐行为和体力活动与白质高密度之间的关系。

简介我们研究了久坐行为（SB）、中到剧烈运动（MVPA）和白质高密度（WMH）体积之间的关系，白质高密度是一种常见的磁共振成像（MRI）标志物，与中老年人患神经退行性疾病的风险有关：我们使用了英国生物库（n = 14,415; 45 至 81 岁）的数据，其中包括加速度计得出的 SB 和 MVPA 测量值，以及 MRI 得出的 WMH 体积：结果：MVPA 和 SB 均与 WMH 体积相关（βMVPA = -0.03 [-0.04, -0.01], p SB = 0.02 [0.01, 0.03], p = 0.007）。SB和MVPA对WMH体积有明显的交互作用（βSB×MVPA = -0.015 [-0.028, -0.001]，p SB×MVPA = 0.03），其中SB与低MVPA时的WMH呈正相关，而MVPA与高SB时的WMH呈负相关：讨论：虽然这项研究不能确定因果关系，但研究结果突出表明，在旨在减少中老年人 WMH 积聚的策略中，同时考虑 MVPA 和 SB 可能非常重要：SB与WMH体积增大有关，而MVPA与WMH体积减小有关。SB与WMH之间的关系在MVPA水平较低时最为密切。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.