HLA-lacking clones in aplastic anaemia: Adaptive or maladaptive?

IF 5.1 2区 医学 Q1 HEMATOLOGY British Journal of Haematology Pub Date : 2024-08-26 DOI:10.1111/bjh.19731
Carmelo Gurnari, Alberto Cardoso Martins Lima, Simona Pagliuca
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Abstract

HLA loss represents the result of immune forces shaping bone marrow clonal dynamics in immune aplastic anaemia. Human leukocyte antigen (HLA)-deficient clones may rescue haematopoiesis by evading immune attacks, potentially guiding treatment strategies. Commentary on: Zaimoku et al. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19712.

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再生障碍性贫血中缺乏 HLA 的克隆:适应性还是适应性不良?
在免疫性再生障碍性贫血中,HLA缺失是免疫力影响骨髓克隆动态的结果。人类白细胞抗原(HLA)缺失克隆可通过逃避免疫攻击来挽救造血功能,从而为治疗策略提供潜在指导。相关评论Zaimoku等:HLA-A*0206缺陷克隆在重型再生障碍性贫血中的造血再生,无需明确的免疫抑制治疗。Br J Haematol 2024(在线提前打印)。doi: 10.1111/bjh.19712。
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来源期刊
CiteScore
8.60
自引率
4.60%
发文量
565
审稿时长
1 months
期刊介绍: The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
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