Association of Molar Incisor Hypomineralization with Hypomineralized Second Primary Molars: An Updated Systematic Review with a Meta-Analysis and Trial Sequential Analysis.

IF 2.9 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Caries Research Pub Date : 2024-08-26 DOI:10.1159/000540752
Zhaoxin Zhang, Yueying Liu, Yaxin Zhu, Jingya Guo, Mingzhen Yang, Yang Lu, Yimeng Zhang, Jie Jia
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Abstract

Introduction: There is a correlation between molar incisor hypomineralization (MIH) and hypomineralized second primary molars (HSPM), but this relationship has not been definitively confirmed. The purpose of this systematic review and meta-analysis was to reevaluate whether children with HSPM are more affected by MIH than non-HSPM children.

Methods: A systematic search was conducted in four databases (PubMed, Embase, Web of Science, and the Cochrane Library) for literature, published up to December 2022. Two independent reviewers conducted the study search and screening, quality assessment, and data extraction according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The risk-of-bias assessment of all included cohort studies and case-control studies was assessed by the Newcastle-Ottawa Scale (NOS), and cross-sectional studies were assessed using the Agency for Healthcare Research Quality (AHRQ) scale. RevMan 5.4 software was used for all data analyses, with odds ratios (ORs) and 95% confidence intervals (CIs) as the effect measures. Sensitivity and subgroup analyses were conducted to identify the potential sources of heterogeneity among the studies. Publication bias was tested and corrected by funnel plots and Egger's test. Trial sequential analysis (TSA) was performed using TSA 0.9.5.10 Beta software to control for type-1 and type-2 errors.

Results: A total of 12 studies involving 8,944 children were included in this meta-analysis. Compared with the non-HSPM group, the HSPM group had an increased likelihood of MIH (OR = 10.90, 95% CI = 4.59-25.89, p < 0.05). All the included studies were of moderate-to-high quality. TSA and sensitivity analyses suggested the robustness of this outcome.

Conclusion: This systematic review demonstrated a certain correlation between HSPM and MIH, suggesting that HSPM can play a predictive role in the occurrence of MIH. Further high-quality, multicenter, and large-sample longitudinal studies are highly recommended.

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臼齿切牙低矿化与第二初级臼齿低矿化的关联:最新的系统综述与荟萃分析和试验序列分析。
导言:臼齿切牙低矿化(MIH)与第二初级臼齿低矿化(HSPM)之间存在相关性,但这种关系尚未得到明确证实。本系统综述和荟萃分析的目的是重新评估患有 HSPM 的儿童是否比非 HSPM 儿童更容易受到 MIH 的影响:在四个数据库(PubMed、Embase、Web of Science 和 Cochrane Library)中对截至 2022 年 12 月发表的文献进行了系统检索。两名独立审稿人根据系统综述和元分析首选报告项目(PRISMA)声明进行了研究检索和筛选、质量评估以及数据提取。所有纳入的队列研究和病例对照研究均采用纽卡斯尔-渥太华量表(NOS)进行偏倚风险评估,横断面研究则采用美国医疗保健研究质量机构(AHRQ)量表进行评估。所有数据分析均使用 RevMan 5.4 软件,并以几率比(OR)和 95% 置信区间(CI)作为效果测量指标。进行了敏感性分析和亚组分析,以确定研究之间潜在的异质性来源。通过漏斗图和 Egger 检验对发表偏倚进行了检验和校正。使用TSA 0.9.5.10 Beta软件进行了试验序列分析(TSA),以控制1型和2型错误:本次荟萃分析共纳入了12项研究,涉及8944名儿童。与非 HSPM 组相比,HSPM 组发生 MIH 的可能性增加(OR = 10.90,95% CI = 4.59-25.89,P <0.05)。所有纳入研究的质量均为中高水平。TSA和敏感性分析表明了这一结果的稳健性:本系统综述显示 HSPM 与 MIH 之间存在一定的相关性,表明 HSPM 对 MIH 的发生具有预测作用。强烈建议进一步开展高质量、多中心和大样本的纵向研究。
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来源期刊
Caries Research
Caries Research 医学-牙科与口腔外科
CiteScore
6.30
自引率
7.10%
发文量
34
审稿时长
6-12 weeks
期刊介绍: ''Caries Research'' publishes epidemiological, clinical and laboratory studies in dental caries, erosion and related dental diseases. Some studies build on the considerable advances already made in caries prevention, e.g. through fluoride application. Some aim to improve understanding of the increasingly important problem of dental erosion and the associated tooth wear process. Others monitor the changing pattern of caries in different populations, explore improved methods of diagnosis or evaluate methods of prevention or treatment. The broad coverage of current research has given the journal an international reputation as an indispensable source for both basic scientists and clinicians engaged in understanding, investigating and preventing dental disease.
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