Effect of a seven-strain probiotic on dietary intake, inflammatory markers, and T-cells in severe traumatic brain injury patients: A randomized, double-blind, placebo-controlled trial.

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Science Progress Pub Date : 2024-07-01 DOI:10.1177/00368504241259299

Seyed Hamze Abbaszadeh, Mehdi Yousefi, Seyed Rafie Arefhosseini, Ata Mahmoodpoor, Mehrangiz Ebrahimi Mameghani

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Abstract

Background: Inflammatory processes are key factors in pathological events associated with severe traumatic brain injury (STBI). The aim of this trial was to determine the effect of probiotics on anthropometric measures, disease severity, inflammatory markers, and T cells in patients with STBI.

Methods: Forty adult patients with STBI were enrolled in this parallel randomized, double-blind, placebo-controlled trial. Energy and protein status, Acute Physiology and Chronic Health Evaluation (APACHE II) score, Sequential Organ Failure Assessment (SOFA), interleukin 10 (IL-10), interleukin 1β (IL-1β), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta (TGF-β), T-helper 17 (Th17), and T- Regulator (T-reg) cells were assessed at baseline (day 1), and week 2 (day 14) for each patient.

Results: Probiotic supplementation led to a substantial reduction in the serum levels of TNF-α (from 10.15 ± 6.52 to 5.05 ± 3.27) (P = 0.034), IL-1β (from 11.84 ± 7.74 to 5.87 ± 3.77) (P < 0.001), and Th17 cells (from 5.19 ± 1.69 to 2.67 ± 1.89) (P < 0.001) and a substantial increase in the serum levels of IL-10 (from 3.35 ± 1.45 to 6.17 ± 2.04) (P = 0.038), TGF-β (from 30.5 ± 15.27 to 46.25 ± 21.05) (P < 0.001), and T-reg cells (from 2.83 ± 1.43 to 4.29 ± 1.89) (P < 0.001) compared with the placebo group. Furthermore, no notable changes were observed in energy and protein intake and also, terms of SOFA and APACHE II scores following probiotic treatment compared with the placebo.

Conclusions: Probiotics could reduce inflammation and improve cellular immunity and may be considered as an adjunctive therapy in STBI patients.

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七种益生菌对严重脑外伤患者饮食摄入量、炎症指标和 T 细胞的影响：随机、双盲、安慰剂对照试验。

背景：炎症过程是严重创伤性脑损伤（STBI）相关病理事件的关键因素。本试验旨在确定益生菌对 STBI 患者的人体测量指标、疾病严重程度、炎症标志物和 T 细胞的影响：这项平行随机、双盲、安慰剂对照试验招募了 40 名 STBI 成年患者。在基线（第1天）和第2周（第14天）对每位患者的能量和蛋白质状态、急性生理学和慢性健康评估（APACHE II）评分、序贯器官衰竭评估（SOFA）、白细胞介素10（IL-10）、白细胞介素1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、转化生长因子β（TGF-β）、T辅助细胞17（Th17）和T调节细胞（T-reg）进行评估：结果：补充益生菌后，血清中 TNF-α（从 10.15 ± 6.52 降至 5.05 ± 3.27）（P = 0.034）、IL-1β（从 11.84 ± 7.74 降至 5.87 ± 3.77）（P P = 0.038）、TGF-β（从 30.5 ± 15.27 降至 46.25 ± 21.05）（P P P 结论：益生菌可以减轻炎症反应：益生菌能减轻炎症反应，改善细胞免疫功能，可作为 STBI 患者的辅助疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Progress Multidisciplinary-Multidisciplinary

CiteScore

3.80

自引率

0.00%

发文量

119

期刊介绍： Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.