AMPK: The energy sensor at the crossroads of aging and cancer

IF 12.1 1区医学 Q1 ONCOLOGY Seminars in cancer biology Pub Date : 2024-08-26 DOI:10.1016/j.semcancer.2024.08.002

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Abstract

AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in response to a variety of physiological stresses, including glucose deprivation, hypoxia, and ischemia. As a kinase with pleiotropic functions, it plays a complex role in tumor progression, exhibiting both tumor-promoting and tumor-suppressing activities. On one hand, AMPK enhances cancer cell proliferation and survival, promotes cancer metastasis, and impairs anti-tumor immunity. On the other hand, AMPK inhibits cancer cell growth and survival and stimulates immune responses in a context-dependent manner. Apart from these functions, AMPK plays a key role in orchestrating aging and aging-related disorders, including cardiovascular diseases (CVD), Osteoarthritis (OA), and Diabetes. In this review article, we summarized the functions of AMPK pathway based on its oncogenic and tumor-suppressive roles and highlighted the importance of AMPK pathway in regulating cellular aging. We also spotlighted the significant role of various signaling pathways, activators, and inhibitors of AMPK in serving as therapeutic strategies for anti-cancer and anti-aging therapy.

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AMPK：衰老与癌症交叉路口的能量传感器

AMP激活蛋白激酶（AMPK）是一种蛋白激酶，在应对葡萄糖剥夺、缺氧和缺血等多种生理应激时发挥多种作用。作为一种具有多种功能的激酶，它在肿瘤进展过程中发挥着复杂的作用，既有促进肿瘤的活性，也有抑制肿瘤的活性。一方面，AMPK 能增强癌细胞的增殖和存活，促进癌症转移，损害抗肿瘤免疫。另一方面，AMPK 可抑制癌细胞的生长和存活，并以环境依赖的方式刺激免疫反应。除了这些功能外，AMPK 在协调衰老和衰老相关疾病（包括心血管疾病（CVD）、骨关节炎（OA）和糖尿病）方面也发挥着关键作用。在这篇综述文章中，我们总结了 AMPK 通路在致癌和抑制肿瘤作用方面的功能，并强调了 AMPK 通路在调节细胞衰老方面的重要性。我们还强调了 AMPK 的各种信号通路、激活剂和抑制剂在抗癌和抗衰老治疗策略中的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.

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