Impact of BMI and Body Composition on First-line Systemic Treatment for Unresectable Hepatocellular Carcinoma.

IF 1.6 4区医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-09-01 DOI:10.21873/anticanres.17239

Takafumi Yamamoto, Takanori Ito, Kazuyuki Mizuno, Shinya Yokoyama, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Hiroki Kawashima

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Abstract

Background/aim: The effects of body mass index (BMI) and body composition on the outcomes of systemic treatment for unresectable hepatocellular carcinoma (uHCC) remain unclear.

Patients and methods: In this retrospective study, patients with uHCC treated with lenvatinib (LEN) or atezolizumab+bevacizumab, were classified into high- (≥25 kg/m²) and low- (<25 kg/m²) BMI groups and evaluated for prognosis. Prognostic impact of body composition was also evaluated.

Results: Patients with a high BMI had lower skeletal mass index (SMI), subcutaneous adipose tissue index (SATI), and visceral adipose tissue index (VATI) compared to those in the low-BMI cohort. The baseline Child-Pugh scores and Barcelona Clinic Liver Cancer stages were comparable between the two cohorts. The overall survival (OS) was better in the high BMI group compared to the low BMI group (median, 913 vs. 484 days; p=0.008). SMI had a strong influence on OS. Additionally, low BMI, VATI, SATI, and visceral-to-subcutaneous fat ratio (VSR) in the LEN treatment group were associated with shorter progression-free survival (PFS).

Conclusion: Following systemic treatment for uHCC, patients with low BMI have a poor prognosis. Among anthropometric factors, low SMI is associated with poor OS. In the LEN treatment group, low VATI may impact PFS negatively.

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体重指数和身体成分对不可切除肝细胞癌一线系统治疗的影响

背景/目的：体重指数（BMI）和身体成分对不可切除肝细胞癌（uHCC）系统治疗结果的影响仍不清楚：在这项回顾性研究中，来伐替尼（LEN）或阿特珠单抗+贝伐单抗治疗的uHCC患者被分为高（≥25 kg/m2）和低（2）BMI组，并对预后进行了评估。同时还评估了身体成分对预后的影响：结果：与低体重指数组相比，高体重指数组患者的骨骼质量指数（SMI）、皮下脂肪组织指数（SATI）和内脏脂肪组织指数（VATI）均较低。两组患者的基线 Child-Pugh 评分和巴塞罗那临床肝癌分期具有可比性。与低体重指数组相比，高体重指数组的总生存期（OS）更长（中位数为913天对484天；P=0.008）。SMI对OS有很大影响。此外，LEN治疗组的低BMI、VATI、SATI和内脏与皮下脂肪比（VSR）与较短的无进展生存期（PFS）相关：结论：在对uHCC进行全身治疗后，低体重指数患者的预后较差。结论：uHCC 患者接受全身治疗后，低体重指数患者的预后较差。在LEN治疗组中，低VATI可能会对PFS产生负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.