Hematoporphyrin photodynamic therapy for treatment of pathological scar with ulceration: A case report

IF 3.1 3区医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2024-08-26 DOI:10.1016/j.pdpdt.2024.104315

Lianheng Xia , Hang Lv , Shaolei Yu , Xiaoqing Xiang , Yanliang Li , Jiaxin Wang , Guozhang Ma , Jie Gao

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Abstract

Pathological scars result from abnormal wound healing and represent a fibrotic process in the repair of skin injuries. Post-burn scars are prone to malignant transformation, especially when ulceration occurs, raising concerns for precancerous lesions. We report a case of a 56-year-old female with a 50-year history of a large burn scar on her left forearm. The scar developed non-healing ulceration with local pain and itching over the past three years. Treatment with hematoporphyrin photodynamic therapy (HpD-PDT) led to resolution of the ulceration, thinning of the scar tissue, and significant alleviation of pain and itching. After a five-year follow-up, there has been no recurrence of ulceration, suggesting that photodynamic therapy effectively promotes wound healing in scarred tissue with ulcerations.

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血卟啉光动力疗法治疗病理性瘢痕溃疡：病例报告。

病理性疤痕是伤口异常愈合的结果，是皮肤损伤修复过程中的纤维化过程。烧伤后的疤痕容易发生恶变，尤其是发生溃疡时，会引起癌前病变的担忧。我们报告了一例 56 岁女性的病例，她左前臂的大面积烧伤疤痕已有 50 年病史。在过去的三年中，该疤痕出现了不愈合的溃疡，并伴有局部疼痛和瘙痒。使用血卟啉光动力疗法（HpD-PDT）治疗后，溃疡消退，疤痕组织变薄，疼痛和瘙痒明显减轻。经过五年的随访，溃疡没有复发，这表明光动力疗法能有效促进溃疡瘢痕组织的伤口愈合。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.