Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics

IF 7.5 1区 医学 Q1 BEHAVIORAL SCIENCES Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-27 DOI:10.1016/j.neubiorev.2024.105867
Yubing Kang , Yee Jie Yeap , Jing Yang , Sufang Ma , Kah Leong Lim , Qin Zhang , Li Lu , Chengwu Zhang
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Abstract

Neurodegenerative diseases (NDDs) are a series of disorders characterized by the progressive loss of specific neurons, leading to cognitive and locomotor impairment. NDDs affect millions of patients worldwide but lack effective treatments. Dysregulation of lipids, particularly the accumulation of lipid droplets (LDs), is strongly implicated in the pathogenesis of NDDs. How LDs contribute to the occurrence and development of NDDs, and their potential as therapeutic targets remain to be addressed. In present review, we first introduce the processes of LDs formation, transportation and degradation. We then highlight how the accumulation of LDs contributes to the pathogenesis of NDDs in a cell type-specific manner. Moreover, we discuss currently available methods for detecting LDs and elaborate on LDs-based therapeutic strategies for NDDs. Lastly, we identify gaps that need to be filled to better leverage LD-based theranostics in NDDs and other diseases. We hope this review could shed light on the role of LDs in NDDs and facilitate the development of novel therapeutic strategies for NDDs.

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脂滴在神经退行性疾病中的作用:从发病机制到治疗方法
神经退行性疾病(NDDs)是一系列以特定神经元逐渐丧失为特征的疾病,会导致认知和运动障碍。NDD 影响着全球数百万患者,但却缺乏有效的治疗方法。脂质失调,尤其是脂滴(LDs)的积累,与 NDDs 的发病机制密切相关。脂滴如何导致 NDD 的发生和发展,以及脂滴作为治疗靶点的潜力仍有待研究。在本综述中,我们首先介绍了 LDs 的形成、运输和降解过程。然后,我们强调了 LDs 的积累是如何以细胞类型特异性的方式导致 NDDs 发病的。此外,我们还讨论了目前可用的 LDs 检测方法,并阐述了基于 LDs 的 NDDs 治疗策略。最后,我们指出了需要填补的空白,以便在 NDDs 和其他疾病中更好地利用基于 LD 的疗法。我们希望这篇综述能阐明 LDs 在 NDDs 中的作用,并促进 NDDs 新型治疗策略的开发。
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来源期刊
CiteScore
14.20
自引率
3.70%
发文量
466
审稿时长
6 months
期刊介绍: The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.
期刊最新文献
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