多项研究已经证实，微生物代谢物失调与肥胖和高血压等疾病的进展之间存在联系。然而，肠道微生物组及其代谢在慢性肾脏病（CKD）中的作用在很大程度上仍不为人所知。一项新的研究表明，约翰逊乳杆菌和微生物衍生的吲哚-3-甲醛（IAld）水平的降低在很大程度上导致了大鼠慢性肾脏病的进展。研究人员发现，在腺嘌呤诱导的慢性肾功能衰竭大鼠体内，约翰逊乳杆菌的数量减少，而补充约翰逊乳杆菌能改善动物的肾脏纤维化。同样，研究小组发现，使用单侧输尿管阻塞和5/6肾切除术诱导CKD的大鼠血清中IAld水平降低，而IAld治疗可减轻肾脏病变。结果还表明，IAld可通过改善肠上皮屏障功能和抑制芳基烃受体（AHR）信号通路来防止肾损伤，为治疗CKD提供了新的潜在途径：Miao, H. et al.Target Ther.9, 195 (2024)
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