A Confused Case Diagnosed as Cerebral Infarction or Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

IF 0.9 Q4 CLINICAL NEUROLOGY Case Reports in Neurological Medicine Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI:10.1155/2024/9941341
Yanan Ding, Li Zhang, Anqi Huang, Xianyue Meng, Xueli Li
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Abstract

In order to discuss the clinical and MRI features, diagnosis, and prevention of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), we reported an adult case of MOG antibody-related disease misdiagnosed as cerebral infarction. This patient's first clinical symptom was limb weakness, that different from previous reports of MOG antibody-related diseases, such as brainstem encephalitis, neuromyelitis optical, and transverse myelitis. The main treatment plan is high-dose corticosteroid therapy combined with immunoglobulin therapy. This case indicated that some MOGAD patients lack of specificity in the clinical manifestations and imaging perhaps would be misdiagnosed as cerebral infarction, encephalitis, immune peripheral neuropathy, MS, NMOSD, and other diseases. For patients with atypical clinical manifestations or imaging, it is especially important to take antibody detection as early as possible to make correct diagnosis and active treatment in time to avoid disability.

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一个被诊断为脑梗塞或髓鞘寡突胶质细胞蛋白抗体相关疾病的疑难病例。
为了探讨髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)的临床和磁共振成像特征、诊断和预防,我们报道了一例被误诊为脑梗塞的成人MOG抗体相关疾病。该患者的首发临床症状是四肢无力,这与之前报道的脑干脑炎、光学神经脊髓炎和横贯性脊髓炎等 MOG 抗体相关疾病不同。主要治疗方案是大剂量皮质类固醇治疗联合免疫球蛋白治疗。该病例表明,部分 MOGAD 患者的临床表现和影像学表现缺乏特异性,可能会被误诊为脑梗塞、脑炎、免疫性周围神经病、多发性硬化症、NMOSD 等疾病。对于临床表现或影像学表现不典型的患者,尽早进行抗体检测,及时做出正确诊断和积极治疗,避免致残尤为重要。
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发文量
26
审稿时长
11 weeks
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