Investigation of the Expression and Regulation of SCG5 in the Context of the Chromogranin-Secretogranin Family in Malignant Tumors.

IF 1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Protein and Peptide Letters Pub Date : 2024-08-30 DOI:10.2174/0109298665325956240819064853
Weisong Zhang, Rui Wang Rui, Zhongquan Yi, Rongqi Guo, Yangyang Li, Yanhan Xu, Xia Li, Jianxiang Song
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Abstract

The SCG5 gene has been demonstrated to play an essential role in the development and progression of a range of malignant neoplasms. The regulation of SCG5 expression involves multiple biological pathways. According to relevant studies, SCG5 is differentially expressed in different cancers, and its up- or down-regulation may even affect tumour growth, invasion, and migration, which caught our attention. Therefore, we summarise the regulatory roles played by the SCG5 gene in a variety of cancers and the biological regulatory mechanisms associated with its possible promotion or inhibition of tumour biological behavior, to further explore the potential of SCG5 as a new tumour marker and hopefully provide theoretical guidance for subsequent disease research and treatment.

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恶性肿瘤中嗜铬粒蛋白-嗜泌粒蛋白家族中 SCG5 的表达和调控研究
SCG5 基因已被证实在一系列恶性肿瘤的发生和发展过程中发挥着重要作用。SCG5 的表达调控涉及多种生物学途径。根据相关研究,SCG5 在不同癌症中的表达存在差异,其上调或下调甚至可能影响肿瘤的生长、侵袭和迁移,这引起了我们的关注。因此,我们总结了SCG5基因在多种癌症中发挥的调控作用,以及其可能促进或抑制肿瘤生物学行为的相关生物学调控机制,进一步探讨SCG5作为一种新的肿瘤标志物的潜力,希望能为后续的疾病研究和治疗提供理论指导。
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来源期刊
Protein and Peptide Letters
Protein and Peptide Letters 生物-生化与分子生物学
CiteScore
2.90
自引率
0.00%
发文量
98
审稿时长
2 months
期刊介绍: Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis
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