{"title":"<i>Pseudomonas aeruginosa</i>: metabolic allies and adversaries in the world of polymicrobial infections.","authors":"Chandni Sachdeva, Kapaettu Satyamoorthy, Thokur Sreepathy Murali","doi":"10.1080/1040841X.2024.2397359","DOIUrl":null,"url":null,"abstract":"<p><p><i>Pseudomonas aeruginosa</i> (PA), an opportunistic human pathogen that is frequently linked with chronic infections in immunocompromised individuals, is also metabolically versatile, and thrives in diverse environments. Additionally, studies report that PA can interact with other microorganisms, such as bacteria, and fungi, producing unique metabolites that can modulate the host immune response, and contribute to disease pathogenesis. This review summarizes the current knowledge related to the metabolic interactions of PA with other microorganisms (<i>Staphylococcus</i>, <i>Acinetobacter</i>, <i>Klebsiella</i>, <i>Enterococcus</i>, and <i>Candida</i>) and human hosts, and the importance of these interactions in a polymicrobial context. Further, we highlight the potential applications of studying these metabolic interactions toward designing better diagnostic tools, and therapeutic strategies to prevent, and treat infections caused by this pathogen.</p>","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/1040841X.2024.2397359","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pseudomonas aeruginosa (PA), an opportunistic human pathogen that is frequently linked with chronic infections in immunocompromised individuals, is also metabolically versatile, and thrives in diverse environments. Additionally, studies report that PA can interact with other microorganisms, such as bacteria, and fungi, producing unique metabolites that can modulate the host immune response, and contribute to disease pathogenesis. This review summarizes the current knowledge related to the metabolic interactions of PA with other microorganisms (Staphylococcus, Acinetobacter, Klebsiella, Enterococcus, and Candida) and human hosts, and the importance of these interactions in a polymicrobial context. Further, we highlight the potential applications of studying these metabolic interactions toward designing better diagnostic tools, and therapeutic strategies to prevent, and treat infections caused by this pathogen.
铜绿假单胞菌（Pseudomonas aeruginosa，PA）是一种机会性人类病原体，经常与免疫力低下人群的慢性感染有关。此外，有研究报告称，PA 能与细菌和真菌等其他微生物相互作用，产生独特的代谢产物，从而调节宿主的免疫反应，促进疾病的发病。本综述总结了 PA 与其他微生物（葡萄球菌、醋烷杆菌、克雷伯氏菌、肠球菌和念珠菌）和人类宿主的代谢相互作用的现有相关知识，以及这些相互作用在多微生物背景下的重要性。此外，我们还强调了研究这些代谢相互作用对设计更好的诊断工具和治疗策略的潜在应用，以预防和治疗由这种病原体引起的感染。
期刊介绍：
Critical Reviews in Microbiology is an international, peer-reviewed journal that publishes comprehensive reviews covering all areas of microbiology relevant to humans and animals, including medical and veterinary microbiology, public health and environmental microbiology. These may include subjects related to microbial molecular biology, immunopathogenicity, physiology, biochemistry, structure, and epidemiology. Of particular interest are reviews covering clinical aspects of bacterial, virological, fungal and parasitic diseases. All reviews must be analytical, comprehensive, and balanced in nature. Editors welcome uninvited submissions, as well as suggested topics for reviews accompanied by an abstract.
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