Tissue engineering and regenerative medicine approaches in colorectal surgery.

IF 3 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of Coloproctology Pub Date : 2024-08-01 Epub Date: 2024-08-30 DOI:10.3393/ac.2024.00437.0062
Bigyan B Mainali, James J Yoo, Mitchell R Ladd
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Abstract

Tissue engineering and regenerative medicine (TERM) is an emerging field that has provided new therapeutic opportunities by delivering innovative solutions. The development of nontraditional therapies for previously unsolvable diseases and conditions has brought hope and excitement to countless individuals globally. Many regenerative medicine therapies have been developed and delivered to patients clinically. The technology platforms developed in regenerative medicine have been expanded to various medical areas; however, their applications in colorectal surgery remain limited. Applying TERM technologies to engineer biological tissue and organ substitutes may address the current therapeutic challenges and overcome some complications in colorectal surgery, such as inflammatory bowel diseases, short bowel syndrome, and diseases of motility and neuromuscular function. This review provides a comprehensive overview of TERM applications in colorectal surgery, highlighting the current state of the art, including preclinical and clinical studies, current challenges, and future perspectives. This article synthesizes the latest findings, providing a valuable resource for clinicians and researchers aiming to integrate TERM into colorectal surgical practice.

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结直肠手术中的组织工程和再生医学方法。
组织工程与再生医学(TERM)是一个新兴领域,它通过提供创新解决方案,为治疗提供了新的机会。针对以前无法解决的疾病和病症开发的非传统疗法为全球无数人带来了希望和兴奋。许多再生医学疗法已经开发出来并应用于临床。再生医学中开发的技术平台已扩展到各个医疗领域,但在结直肠外科中的应用仍然有限。应用 TERM 技术来设计生物组织和器官替代物,可以解决当前的治疗难题,并克服结直肠手术中的一些并发症,如炎症性肠病、短肠综合征以及运动和神经肌肉功能疾病。这篇综述全面概述了 TERM 在结直肠手术中的应用,重点介绍了当前的技术水平,包括临床前和临床研究、当前挑战和未来展望。这篇文章综合了最新研究成果,为旨在将 TERM 纳入结直肠外科实践的临床医生和研究人员提供了宝贵的资源。
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来源期刊
CiteScore
3.30
自引率
3.20%
发文量
73
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