Relationship between the atherogenic index of plasma and the prevalence of kidney stones: insights from a population-based cross-sectional study.

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-09-04 DOI:10.1080/0886022X.2024.2390566
Dawei Wang, Feng Shi, Dingguo Zhang, Lin Zhang, Hui Wang, Zijian Zhou, Yu Zhu
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Abstract

Objective: To investigate the association between atherogenic index of plasma (AIP) and kidney stones (KS) occurrence and recurrence.

Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2014. Non-pregnant adults who provided complete information on AIP and KS were included in the analyses. AIP was calculated as log (triglyceride/high-density lipoprotein cholesterol). KS was ascertained with questionnaires. Weighted multivariable logistic regression model and restricted cubic spline (RCS) were applied to examine the associations between AIP and KS occurrence and recurrence.

Results: A total of 6488 subjects (weighted mean age 43.19 years and 49.26% male) with a weighted mean AIP of 0.66 were included in this study. The multivariable-adjusted OR for nephrolithiasis occurrence across consecutive tertiles was 1.00 (reference), 1.21 (95% CI: 0.90-1.62), and 1.85 (95% CI: 1.39-2.48), respectively. Moreover, each SD increment of AIP was associated with a 50% (OR:1.50, 95% CI: 1.25-1.81) higher risk of nephrolithiasis recurrence. RCSs showed significant and linear dose-response relationships between AIP and nephrolithiasis occurrence (p-overall = 0.006, p-nonlinear = 0.689) and recurrence (p-overall = 0.001, p-nonlinear = 0.848). The positive associations between AIP and nephrolithiasis occurrence and recurrence persisted in sensitivity analyses, suggesting the robustness of the results.

Conclusion: In the current US nationally representative cross-sectional study, AIP was positively associated with KS occurrence and recurrence.

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血浆致动脉粥样硬化指数与肾结石发病率之间的关系:一项基于人群的横断面研究的启示。
目的研究血浆致动脉粥样硬化指数(AIP)与肾结石(KS)发生和复发之间的关系:数据来自 2007-2014 年美国国家健康与营养调查(NHANES)。分析纳入了提供完整 AIP 和 KS 信息的非怀孕成年人。AIP 以对数(甘油三酯/高密度脂蛋白胆固醇)计算。KS 通过问卷调查确定。应用加权多变量逻辑回归模型和限制性立方样条曲线(RCS)研究AIP与KS发生和复发之间的关系:本研究共纳入 6488 名受试者(加权平均年龄为 43.19 岁,49.26% 为男性),加权平均 AIP 为 0.66。经多变量调整后,不同连续分层的肾结石发生率分别为 1.00(参考值)、1.21(95% CI:0.90-1.62)和 1.85(95% CI:1.39-2.48)。此外,AIP 每增加一个 SD 值,肾结石复发的风险就会增加 50%(OR:1.50,95% CI:1.25-1.81)。RCS 显示,AIP 与肾结石发生率(总体 p=0.006,非线性 p=0.689)和复发率(总体 p=0.001,非线性 p=0.848)之间存在明显的线性剂量反应关系。AIP与肾结石发生和复发之间的正相关关系在敏感性分析中依然存在,这表明研究结果具有稳健性:在目前这项具有美国全国代表性的横断面研究中,AIP 与 KS 的发生和复发呈正相关。
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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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