Intermolecular Sulfenoamination of Alkenes with Free-Thiols and NIS to Access β-Succinimide Sulfides.

IF 3.5 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - An Asian Journal Pub Date : 2024-09-04 DOI:10.1002/asia.202400945
Wei Chen, Wanxiang Wang, Run Wu, Haiping Zhou, Pingbing Yu
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Abstract

A convenient and practical multicomponent strategy for the sulfenoamination of alkenes was realized, which using free-thiols as the sulfur-reagent, NIS both as radical initiator and an N-nucleophile. This protocol excellent in terms of transition-metal-free, good functional group tolerance, easily available substrates and facile scale-up. And provided a direct- and general way to synthesize various β-succinimide sulfides with high regioselectivity.

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用游离硫醇和 NIS 对烯进行分子间亚硫酰氨基化,以获得 β-琥珀酰亚胺硫化物。
利用游离硫醇作为硫试剂、NIS 作为自由基引发剂和 N-亲核剂,实现了一种方便实用的烯烃亚硫酰氨基化多组分策略。该方法不含过渡金属,对官能团有良好的耐受性,底物容易获得,易于推广。它为高区域选择性地合成各种 β-琥珀酰亚胺硫化物提供了一种直接而通用的方法。
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来源期刊
Chemistry - An Asian Journal
Chemistry - An Asian Journal 化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍: Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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