Gout or Hyperuricemia and Dementia Risk: A Meta-Analysis of Observational Studies.

IF 3.4 3区医学 Q2 NEUROSCIENCES Journal of Alzheimer's Disease Pub Date : 2024-09-03 DOI:10.3233/JAD-240076

Yirou Yao, Shun Zhu, Jingnian Ni, Mingqing Wei, Ting Li, Siwei Long, Jing Shi, Jinzhou Tian

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Abstract

Background: As a natural antioxidant, uric acid has neuroprotective effects. The association between uric acid levels and dementia risk was reported by previous studies. However, recently published studies showed that the relationship between uric acid and dementia risk might be heterogeneous in dementia subtypes.

Objective: This study aimed to clarify the relationship between hyperuricemia (or gout) and dementia.

Methods: The PubMed and Web of Science databases were systematically searched up to April 2024 to identify relevant studies. A meta-analysis was conducted using hazard ratios (HR) or odds ratios (OR) and 95% confidence interval (CI) as pooled indicators. Heterogeneity between the studies was examined using Cochran's Q statistic and I2 statistic. Subgroup analyses were conducted for gender and age. Stratification analysis, sensitivity analyses and meta-regression were conducted to explore possible explanations for heterogeneity. Publication bias was assessed by funnel plot and Egger's test.

Results: A total of 11 studies met the inclusion criteria including 2,928,152 participants were abstracted. Hyperuricemia (or gout) did not reduce the overall risk of dementia (OR/HR = 0.92, 95% CI: 0.81-1.05) and vascular dementia (OR/HR = 0.74, 95% CI: 0.53-1.05), but may have a protective effect against Alzheimer's disease (OR/HR = 0.82, 95% CI: 0.70-0.96). Subgroup analysis showed that a lower risk of dementia was observed in men (OR/HR = 0.83, 95% CI: 0.77-0.90) and patients whose age under 65 (OR/HR = 0.83, 95% CI: 0.72-0.95).

Conclusions: Patients with gout or hyperuricemia have a low risk of Alzheimer's disease.

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痛风或高尿酸血症与痴呆症风险：观察性研究的 Meta 分析。

背景：作为一种天然抗氧化剂，尿酸具有保护神经的作用。以前的研究曾报道过尿酸水平与痴呆症风险之间的关系。然而，最近发表的研究表明，尿酸与痴呆症风险之间的关系在痴呆症亚型中可能存在异质性：本研究旨在阐明高尿酸血症（或痛风）与痴呆症之间的关系：方法：系统检索了截至2024年4月的PubMed和Web of Science数据库，以确定相关研究。采用危险比（HR）或几率比（OR）和95%置信区间（CI）作为汇总指标进行荟萃分析。研究之间的异质性采用 Cochran's Q 统计量和 I2 统计量进行检验。对性别和年龄进行了分组分析。进行了分层分析、敏感性分析和元回归，以探索异质性的可能解释。通过漏斗图和 Egger 检验评估了发表偏倚：共摘录了 11 项符合纳入标准的研究，包括 2,928,152 名参与者。高尿酸血症（或痛风）并未降低痴呆症（OR/HR = 0.92，95% CI：0.81-1.05）和血管性痴呆症（OR/HR = 0.74，95% CI：0.53-1.05）的总体风险，但可能对阿尔茨海默病有保护作用（OR/HR = 0.82，95% CI：0.70-0.96）。亚组分析显示，男性（OR/HR = 0.83，95% CI：0.77-0.90）和年龄在65岁以下的患者患痴呆症的风险较低（OR/HR = 0.83，95% CI：0.72-0.95）：结论：痛风或高尿酸血症患者罹患阿尔茨海默病的风险较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.