Emerging roles of hydrogen sulfide in colorectal cancer

IF 4.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemico-Biological Interactions Pub Date : 2024-09-03 DOI:10.1016/j.cbi.2024.111226

Zhi-Liang Jiang , Yi Liu , Chuan-Hao Zhang , Ti Chu , Yi-Lun Yang , Yi-Wen Zhu , Yan Wang , Ya-Fang Liu , Yan-Xia Zhang , Zhi-Fen Feng , Xin-Ying Ji , Dong-Dong Wu

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Abstract

Hydrogen sulfide (H₂S), an endogenous gasotransmitter, plays a key role in several critical physiological and pathological processes in vivo, including vasodilation, anti-infection, anti-tumor, anti-inflammation, and angiogenesis. In colorectal cancer (CRC), aberrant overexpression of H₂S-producing enzymes has been observed. Due to the important role of H₂S in the proliferation, growth, and death of cancer cells, H₂S can serve as a potential target for cancer therapy. In this review, we thoroughly analyzed the underlying mechanism of action of H₂S in CRC from the following aspects: the synthesis and catabolism of H₂S in CRC cells and its effect on cell signal transduction pathways; the inhibition effects of exogenous H₂S donors with different concentrations on the growth of CRC cells and the underlying mechanism of H₂S in garlic and other natural products. Furthermore, we elucidate the expression characteristics of H₂S in CRC and construct a comprehensive H₂S-related signaling pathway network, which has important basic and practical significance for promoting the clinical research of H₂S-related drugs.

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硫化氢在结直肠癌中的新作用。

硫化氢（H2S）是一种内源性气体递质，在体内多个关键的生理和病理过程中发挥着重要作用，包括扩张血管、抗感染、抗肿瘤、抗炎和血管生成。在结直肠癌（CRC）中，已观察到 H2S 生成酶的异常过表达。由于 H2S 在癌细胞增殖、生长和死亡中的重要作用，H2S 信号通路可作为癌症治疗的潜在靶点。在这篇综述中，我们从以下几个方面深入分析了 H2S 在 CRC 中的作用机制：H2S 在 CRC 细胞中的合成和分解及其对细胞信号传导通路的影响；不同浓度的外源性 H2S 供体对 CRC 细胞生长的抑制作用以及大蒜和其他天然产物中 H2S 的作用机制。此外，我们还阐明了H2S在CRC中的表达特点，构建了一个全面的H2S相关信号通路网络，对促进H2S相关药物的临床研究具有重要的基础和现实意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemico-Biological Interactions 生物-毒理学

CiteScore

7.70

自引率

3.90%

发文量

410

审稿时长

36 days

期刊介绍： Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.