Hypoalbuminemia on admission in diabetic patients correlates with severity of illness in COVID-19: A retrospective clinical study and literature review

Q3 Medicine Endocrine and Metabolic Science Pub Date : 2024-09-03 DOI:10.1016/j.endmts.2024.100196

Mayumi Shoji , Naoya Teramoto , Takahiro Ishikawa , Aiko Hayashi , Ai Matsumoto , Hidetoshi Ochiai , Ayano Yamaguchi , Yukari Maeda , Atsushi Takasaki , Chihiro Hiraga , Shintaro Ide , Kana Ide , Masashi Yamamoto , Yoshiro Maezawa , Ayako Shigeta , Seiichiro Sakao , Takuji Suzuki , Misuzu Yahaba , Toshihumi Taniguchi , Hidetoshi Igari , Masaya Koshizaka

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Abstract

Introduction

To elucidate factors associated with severe disease in patients with coronavirus disease 2019 (COVID-19) pneumonia complicated with diabetes mellitus.

Methods

Among patients with COVID-19 pneumonia hospitalized from January to September 2021, 100 patients with diabetes were included in the study. Patients in the intensive care unit admission or in-hospital death category were defined as the severe group (26 patients), and the other patients as the moderate group (74 patients). Comparisons were made between the two groups. Medical histories were extracted from the medical records, and statistical analysis was performed.

Results

Patients were 62.1 ± 13.0 years of age, 70 % male, 48 % aged 65 years and more, and HbA1c was 7.72 ± 1.51 %. The severe group had significantly higher blood glucose level, CRP, WBC, and LDH on admission. Serum albumin level was significantly lower in the severe group and was significantly negatively correlated with number of days on oxygen administration (r = 0.447) and maximal oxygen concentration (r = 0.561). Multiple logistic regression analysis with severity of illness as the objective variable showed that high CRP and low albumin levels on admission, and older age were independently associated.

Conclusions

Low albumin levels on admission may be an indicator of severe disease in patients with diabetes.

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糖尿病患者入院时的低白蛋白血症与 COVID-19 的病情严重程度相关：回顾性临床研究和文献综述

导言：目的：阐明冠状病毒病2019（COVID-19）肺炎并发糖尿病患者的重症相关因素。方法：在2021年1月至9月住院的COVID-19肺炎患者中，纳入100名糖尿病患者。将入住重症监护室或院内死亡的患者定义为重度组（26 例），其他患者定义为中度组（74 例）。对两组患者进行比较。从病历中提取病史，并进行统计分析。结果患者年龄为（62.1 ± 13.0）岁，男性占 70%，65 岁及以上占 48%，HbA1c 为（7.72 ± 1.51）%。重症组患者入院时的血糖水平、CRP、白细胞和 LDH 明显较高。严重组的血清白蛋白水平明显较低，且与吸氧天数（r = 0.447）和最大氧浓度（r = 0.561）呈显著负相关。以病情严重程度为客观变量的多元逻辑回归分析表明，入院时的高 CRP 和低白蛋白水平与年龄较大有独立关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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