Immune checkpoint inhibitors in infectious disease.

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-09-09 DOI:10.1111/imr.13388
Hannah A D King, Sharon R Lewin
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Abstract

Following success in cancer immunotherapy, immune checkpoint blockade is emerging as an exciting potential treatment for some infectious diseases, specifically two chronic viral infections, HIV and hepatitis B. Here, we will discuss the function of immune checkpoints, their role in infectious disease pathology, and the ability of immune checkpoint blockade to reinvigorate the immune response. We focus on blockade of programmed cell death 1 (PD-1) to induce durable immune-mediated control of HIV, given that anti-PD-1 can restore function to exhausted HIV-specific T cells and also reverse HIV latency, a long-lived form of viral infection. We highlight several key studies and future directions of research in relation to anti-PD-1 and HIV persistence from our group, including the impact of immune checkpoint blockade on the establishment (AIDS, 2018, 32, 1491), maintenance (PLoS Pathog, 2016, 12, e1005761; J Infect Dis, 2017, 215, 911; Cell Rep Med, 2022, 3, 100766) and reversal of HIV latency (Nat Commun, 2019, 10, 814; J Immunol, 2020, 204, 1242), enhancement of HIV-specific T cell function (J Immunol, 2022, 208, 54; iScience, 2023, 26, 108165), and investigating the effects of anti-PD-1 and anti-CTLA-4 in vivo in people with HIV on ART with cancer (Sci Transl Med, 2022, 14, eabl3836; AIDS, 2021, 35, 1631; Clin Infect Dis, 2021, 73, e1973). Our future work will focus on the impact of anti-PD-1 in vivo in people with HIV on ART without cancer and potential combinations of anti-PD-1 with other interventions, including therapeutic vaccines or antibodies and less toxic immune checkpoint blockers.

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传染病中的免疫检查点抑制剂。
继癌症免疫疗法取得成功之后,免疫检查点阻断疗法正在成为治疗某些传染病(特别是艾滋病和乙型肝炎这两种慢性病毒感染)的一种令人兴奋的潜在疗法。在这里,我们将讨论免疫检查点的功能、它们在传染病病理学中的作用以及免疫检查点阻断疗法重振免疫反应的能力。鉴于抗 PD-1 能恢复衰竭的 HIV 特异性 T 细胞的功能,还能逆转 HIV 潜伏期(一种长效的病毒感染形式),我们将重点讨论通过阻断程序性细胞死亡 1(PD-1)来诱导对 HIV 的持久免疫控制。我们重点介绍了我们课题组有关抗PD-1和HIV持续性的几项关键研究和未来研究方向,包括免疫检查点阻断对HIV潜伏期的建立(AIDS,2018,32,1491)、维持(PLoS Pathog,2016,12,e1005761;J Infect Dis,2017,215,911;Cell Rep Med,2022,3,100766)和逆转的影响(Nat Commun,2019,10,814;J Immunol, 2020, 204, 1242)、增强HIV特异性T细胞功能(J Immunol, 2022, 208, 54;iScience, 2023, 26, 108165),以及研究抗PD-1和抗CTLA-4在体内对接受抗逆转录病毒疗法的HIV癌症患者的影响(Sci Transl Med, 2022, 14, eabl3836;AIDS, 2021, 35, 1631;Clin Infect Dis, 2021, 73, e1973)。我们未来的工作将重点关注体内抗 PD-1 对接受抗逆转录病毒疗法但未患癌症的 HIV 感染者的影响,以及抗 PD-1 与其他干预措施(包括治疗性疫苗或抗体以及毒性较低的免疫检查点阻断剂)的潜在组合。
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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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