A Dynamic Interplay of Innate Immune Responses During Urinary Tract Infection.

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2024-07-22 eCollection Date: 2024-08-01 DOI:10.4110/in.2024.24.e31
Manisha Naskar, Hae Woong Choi
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Abstract

Urinary tract infections (UTIs) represent one of the most prevalent bacterial infections globally, manifesting in diverse clinical phenotypes with varying degrees of severity and complications. The mechanisms underlying UTIs are gradually being elucidated, leading to an enhanced understanding of the immune responses involved. Innate immune cells play a crucial defensive role against uropathogenic bacteria through various mechanisms. Despite their significant contributions to host defense, these cells often fail to achieve complete clearance of uropathogens, necessitating the frequent prescription of antibiotics for UTI patients. However, the persistence of infections and related pathological symptoms in the absence of innate immune cells in animal models underscore the importance of innate immunity in UTIs. Therefore, the host protective functions of innate immune cells, including neutrophils, macrophages, mast cells, NK cells, innate lymphoid cells, and γδ T cells, are delicately coordinated and timely regulated by a variety of cytokines to ensure successful pathogen clearance.

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尿路感染期间先天性免疫反应的动态相互作用
尿路感染(UTI)是全球最常见的细菌感染之一,临床表现多种多样,严重程度和并发症也各不相同。尿路感染的发病机制正逐渐被阐明,从而加深了人们对相关免疫反应的了解。先天性免疫细胞通过各种机制对尿路致病菌发挥着重要的防御作用。尽管先天性免疫细胞对宿主防御做出了重要贡献,但它们往往无法完全清除尿路病原体,因此尿路感染患者必须经常使用抗生素。然而,在动物模型中,在先天性免疫细胞缺失的情况下,感染和相关病理症状仍会持续,这凸显了先天性免疫在UTI 中的重要性。因此,先天性免疫细胞(包括中性粒细胞、巨噬细胞、肥大细胞、NK 细胞、先天性淋巴细胞和 γδ T 细胞)对宿主的保护功能受到各种细胞因子的微妙协调和及时调控,以确保成功清除病原体。
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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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