The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections.

IF 4.3 4区医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2024-06-27 eCollection Date: 2024-08-01 DOI:10.4110/in.2024.24.e29

Thamer A Hamdan

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Abstract

NK cells belong to innate lymphoid cells and able to eliminate infected cells and tumor cells. NK cells play a valuable role in controlling viral infections. Also, they have the potential to shape the adaptive immunity via a unique crosstalk with the different immune cells. Murine models are important tools for delineating the immunological phenomena in viral infection. To decipher the immunological virus-host interactions, two major infection models are being investigated in mice regarding NK cell-mediated recognition: murine cytomegalovirus (MCMV) and lymphocytic choriomeningitis virus (LCMV). In this review, we recapitulate recent findings regarding the multifaceted role of NK cells in controlling LCMV and MCMV infections and outline the exquisite interplay between NK cells and other immune cells in these two settings. Considering that, infections with MCMV and LCMV recapitulates many physiopathological characteristics of human cytomegalovirus infection and chronic virus infections respectively, this study will extend our understanding of NK cells biology in interactions between the virus and its natural host.

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NK细胞在巨细胞病毒和淋巴细胞色素膜炎病毒感染中的多方面作用

NK 细胞属于先天性淋巴细胞，能够清除受感染的细胞和肿瘤细胞。NK 细胞在控制病毒感染方面发挥着重要作用。此外，NK 细胞还能通过与不同免疫细胞之间的独特串扰，形成适应性免疫。小鼠模型是描述病毒感染免疫现象的重要工具。为了破译病毒与宿主之间的免疫学相互作用，目前正在小鼠中研究 NK 细胞介导识别的两种主要感染模型：鼠巨细胞病毒（MCMV）和淋巴细胞性脉络膜炎病毒（LCMV）。在这篇综述中，我们回顾了有关 NK 细胞在控制 LCMV 和 MCMV 感染中的多方面作用的最新发现，并概述了 NK 细胞和其他免疫细胞在这两种情况下的微妙相互作用。考虑到 MCMV 和 LCMV 感染分别再现了人类巨细胞病毒感染和慢性病毒感染的许多生理病理特征，本研究将扩展我们对 NK 细胞在病毒与其自然宿主相互作用中的生物学作用的理解。

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来源期刊

Immune Network Immunology and Microbiology-Immunology

CiteScore

2.90

自引率

3.30%

发文量

期刊介绍： Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity