Pleiotropic effects of double filtration plasmapheresis.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2024-12-01 Epub Date: 2024-09-08 DOI:10.1111/1744-9987.14194

Ryuichiro Hirano, Kenichiro Namazuda

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Abstract

Double filtration plasmapheresis (DFPP) is a semi-selective blood purification modality derived from the plasma exchange modality. DFPP can be applied to a variety of refractory disorders including metabolic disorders, organ transplants, rheumatic disorders, neurological disorders, and dermatologic disorders. Familial hypercholesterolemia and lipoprotein (a) hyperlipoproteinemia are major chronic metabolic disorders. Lipoprotein apheresis (LA) is applied for those patients to remove low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) (Lp(a)). DFPP is used as one of the modalities in LA. In addition to removing LDL-C and Lp(a), DFPP has pleiotropic effects such as removal of lipid metabolism-related substances, C-reactive protein lowering effect, removal of adhesion molecules, removal of inflammatory cytokines, and anti-oxidative effect. This article summarizes the pleiotropic effects of DFPP based on recent clinical articles.

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双滤过性血浆置换术的多重效应

双滤过血浆置换术（DFPP）是从血浆置换术中衍生出来的一种半选择性血液净化方式。DFPP 可用于各种难治性疾病，包括代谢性疾病、器官移植、风湿性疾病、神经系统疾病和皮肤病。家族性高胆固醇血症和脂蛋白（a）高脂蛋白血症是主要的慢性代谢性疾病。脂蛋白清除术（LA）适用于这些患者，以清除低密度脂蛋白胆固醇（LDL-C）和脂蛋白（a）（Lp（a））。DFPP是LA的一种模式。除清除低密度脂蛋白胆固醇和脂蛋白（a）外，DFPP 还具有多种效应，如清除脂质代谢相关物质、降低 C 反应蛋白、清除粘附分子、清除炎性细胞因子和抗氧化作用。本文根据最近的临床文章总结了 DFPP 的多效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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