Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone

IF 48.8 1区 医学 Q1 CELL BIOLOGY Cancer Cell Pub Date : 2024-09-09 DOI:10.1016/j.ccell.2024.08.014
Anthony R. Cillo, John M. Kirkwood
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引用次数: 0

Abstract

Combination immunotherapy improves outcomes in metastatic melanoma, but the underlying mechanisms remain unclear. In this issue of Cancer Cell, Wang et al.1 report dynamics and transcriptional states of CD8+ T cell clones over time in patients treated with anti-PD-1, anti-CTLA-4, or a combination of the two. These findings have important implications for understanding and monitoring combination immunotherapy.

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使用 Cyclone 可轻松评估免疫疗法后 T 细胞随时间发生的克隆变化
联合免疫疗法能改善转移性黑色素瘤的治疗效果,但其潜在机制仍不清楚。在本期《癌细胞》(Cancer Cell)杂志上,Wang等人1报告了接受抗PD-1、抗CTLA-4或两者联合治疗的患者CD8+T细胞克隆的动态和转录状态。这些发现对理解和监测联合免疫疗法具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Cell
Cancer Cell 医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍: Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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