{"title":"Nitrogenous compounds from the Seeds of Sinapis alba","authors":"Xue Liu , Degang Kong , Liang Ding , Honglei Zhou","doi":"10.1016/j.phytol.2024.08.009","DOIUrl":null,"url":null,"abstract":"<div><p>The dried and mature seeds of <em>Sinapis alba</em> were investigated. Two undescribed nitrogenous compounds, 3-(4′-hydroxybenzyloxy) pent-4-enenitrile (<strong>1</strong>), <em>N, N</em>-bis[(4-hydroxyphenyl)methyl] ethyl carbamate (<strong>2</strong>), together with two new natural products, <em>N</em>-(4-hydroxybenzyl) ethyl carbamate (<strong>3</strong>), 4-hydroxy-<em>N</em>-(4-hydroxyphenyl)benzeneacetamide (<strong>4</strong>), were isolated from the Seeds of <em>Sinapis alba</em>. The structures of the four compounds were elucidated by NMR and HR-ESI–MS analyses. The anti-inflammatory activity of compounds <strong>1</strong>, <strong>2</strong>, and <strong>4</strong> was screened using the zebrafish inflammation model induced by CuSO<sub>4</sub>, which showed that compounds <strong>1</strong>, <strong>2</strong>, and <strong>4</strong> had obvious anti-inflammatory activity.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 101-106"},"PeriodicalIF":1.3000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001265","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
The dried and mature seeds of Sinapis alba were investigated. Two undescribed nitrogenous compounds, 3-(4′-hydroxybenzyloxy) pent-4-enenitrile (1), N, N-bis[(4-hydroxyphenyl)methyl] ethyl carbamate (2), together with two new natural products, N-(4-hydroxybenzyl) ethyl carbamate (3), 4-hydroxy-N-(4-hydroxyphenyl)benzeneacetamide (4), were isolated from the Seeds of Sinapis alba. The structures of the four compounds were elucidated by NMR and HR-ESI–MS analyses. The anti-inflammatory activity of compounds 1, 2, and 4 was screened using the zebrafish inflammation model induced by CuSO4, which showed that compounds 1, 2, and 4 had obvious anti-inflammatory activity.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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