Single-Administration Self-Boosting Microneedle Patch for the Treatment of Obesity (Adv. Therap. 9/2024)

IF 3.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY Advanced Therapeutics Pub Date : 2024-09-11 DOI:10.1002/adtp.202470019
Parbeen Singh, Tra Vinikoor, Nidhi Sharma, Nicole Nelson, Somasundaram Prasadh, Ralph Oiknine, Thanh Duc Nguyen
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Abstract

GLP-1 RAs are effective therapies for obesity which affects 70% of American adults. However, frequent subcutaneous injections pose challenges for patients and the environment. Here, a programmable scheduled microneedle system is introduced, delivering Semaglutide instantaneously and longitudinally over a month with one skin patch administration. This sustains the drug efficacy and addresses common issues of traditional administration using multiple injections such as pain, needle phobia, high cost and the need of medical personnel, ensuring effective obesity management. More details can be found in article 2400028 by Thanh Duc Nguyen and co-workers.

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用于治疗肥胖症的单次给药自增效微针贴片(Adv. Therap.)
70% 的美国成年人患有肥胖症,GLP-1 RAs 是治疗肥胖症的有效疗法。然而,频繁的皮下注射给患者和环境带来了挑战。这里介绍的是一种可编程的定时微针系统,只需贴一次皮肤,就能在一个月内即时、纵向地给药塞马鲁肽。这样既能保持药物疗效,又能解决传统多次注射给药的常见问题,如疼痛、针头恐惧症、高成本和对医务人员的需求等,确保有效控制肥胖。更多详情,请参阅 Thanh Duc Nguyen 及其合作者撰写的文章 2400028。
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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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