Ming-Jen Cheng , Jih-Jung Chen , Hsia-Wei Liu , Jyh-Yih Leu , Ming-Der Wu , Min Tseng
{"title":"Isolation and antifungal activity assessment of natural compounds from the culture medium of actinobacterium Streptomyces sp. BC129-2","authors":"Ming-Jen Cheng , Jih-Jung Chen , Hsia-Wei Liu , Jyh-Yih Leu , Ming-Der Wu , Min Tseng","doi":"10.1016/j.phytol.2024.08.002","DOIUrl":null,"url":null,"abstract":"<div><p>Two previously undescribed compounds, including one phenylpropanoid derivative, BC129–2 (<strong>1</strong>) and one <em>p</em>-menthane analogue, <em>cis</em>-<em>p</em>-menthane-7,8-diol (<strong>2</strong>), were isolated from the EtOAc-soluble fraction of the culture broth of an actinomycete <em>Streptomyces</em> sp. BC129–2. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that 2 constituents (compounds <strong>1</strong> & <strong>2</strong>) possessed mild antifungal activity against <em>Fusarium</em> sp. LC8, <em>Neopestalotiopsis</em> sp. BCRC 35002, and <em>Colletotrichum gloeosporioides</em> BCRC 35178. It is worth mentioning that the chemical composition of the type strain <em>Streptomyces</em> sp. BC129–2 has never been studied.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 1-5"},"PeriodicalIF":1.3000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001228","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Two previously undescribed compounds, including one phenylpropanoid derivative, BC129–2 (1) and one p-menthane analogue, cis-p-menthane-7,8-diol (2), were isolated from the EtOAc-soluble fraction of the culture broth of an actinomycete Streptomyces sp. BC129–2. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that 2 constituents (compounds 1 & 2) possessed mild antifungal activity against Fusarium sp. LC8, Neopestalotiopsis sp. BCRC 35002, and Colletotrichum gloeosporioides BCRC 35178. It is worth mentioning that the chemical composition of the type strain Streptomyces sp. BC129–2 has never been studied.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
