Li-Wen Shen , Nian Luo , Yun-Qing Jia , Guang-Wei Wang , Shu-Pei Yuan , Min Xiang
{"title":"Lewis base promoted [4 + 2] annulation of o-acylamino-aryl MBH carbonates with isatin†","authors":"Li-Wen Shen , Nian Luo , Yun-Qing Jia , Guang-Wei Wang , Shu-Pei Yuan , Min Xiang","doi":"10.1039/d4ob01240b","DOIUrl":null,"url":null,"abstract":"<div><div>The first example of Lewis base promoted [4 + 2] annulation between <em>o</em>-acylamino-aryl MBH carbonates and isatin has been developed. This methodology exhibits excellent substrate applicability and has synthesized 1,4-dihydrospiro benzo[<em>d</em>][1,3]oxazine-oxindoles with yields up to 98%. The practical value of this method is underscored by its successful application in a 50-fold scale-up.</div></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024007997","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
The first example of Lewis base promoted [4 + 2] annulation between o-acylamino-aryl MBH carbonates and isatin has been developed. This methodology exhibits excellent substrate applicability and has synthesized 1,4-dihydrospiro benzo[d][1,3]oxazine-oxindoles with yields up to 98%. The practical value of this method is underscored by its successful application in a 50-fold scale-up.
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