Activating Methanol for Chemoselective Transfer Hydrogenation of Chalcones Using an SNS-Ruthenium Complex

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-09-09 DOI:10.1055/a-2384-6441
Kailash Mohar, Hirak Jyoti Phukan, Avijit Mondal, Kaushik Soni, Dipankar Srimani
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Abstract

Methanol is gaining popularity as a transfer-hydrogenating agent in catalytic reduction reactions because of its bulk-scale production and inexpensive nature. Current research interests include the utilization of methanol as a safe and sustainable hydrogen source for chemical synthesis and drug development. In particular, the chemoselective reduction of α,β-unsaturated ketones is of great interest because of their prevalence in many natural products. We investigated the potential application of acridine-derived SNS-Ru pincer complexes in methanol activation for chemoselective reduction of chalcones. Our developed catalytic system showed broad substrate tolerance, including substrates containing reducible functional groups. Control experiments and postsynthetic applications are also highlighted.

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利用 SNS-Ruthenium 复合物活化甲醇以进行查耳酮的化学选择性转移加氢反应
甲醇作为催化还原反应中的转移加氢剂,因其批量生产和价格低廉而越来越受欢迎。目前的研究兴趣包括将甲醇作为一种安全、可持续的氢源用于化学合成和药物开发。特别是,α、β-不饱和酮的化学选择性还原反应引起了极大的兴趣,因为它们在许多天然产品中普遍存在。我们研究了吖啶衍生的 SNS-Ru 钳子配合物在甲醇活化中化学选择性还原查耳酮的潜在应用。我们开发的催化系统对底物具有广泛的耐受性,包括含有可还原官能团的底物。此外,还重点介绍了对照实验和合成后的应用。
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来源期刊
Synlett
Synlett 化学-有机化学
CiteScore
3.40
自引率
5.00%
发文量
369
审稿时长
1 months
期刊介绍: SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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