An Overview of Secondary Metabolites from Soft Corals of the Genus Capnella over the Five Decades: Chemical Structures, Pharmacological Activities, NMR Data, and Chemical Synthesis

IF 4.9 2区 医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2024-09-02 DOI:10.3390/md22090402
Can-Qi Liu, Qi-Bin Yang, Ling Zhang, Lin-Fu Liang
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Abstract

There has been no specific review on the secondary metabolites from soft corals of the genus Capnella till now. In this work, all secondary metabolites from different species of the title genus were described. It covered the first work from 1974 to May 2024, spanning five decades. In the viewpoint of the general structural features, these chemical constituents were classified into four groups: sesquiterpenes, diterpenes, steroids, and lipids. Additionally, the 1H and 13C NMR data of these metabolites were provided when available in the literature. Among them, sesquiterpenes were the most abundant chemical compositions from soft corals of the genus Capnella. A variety of pharmacological activities of these compounds were evaluated, such as cytotoxic, antibacterial, antifungal, and anti-inflammatory activities. In addition, the chemical synthesis works of several representative sesquiterpenes were provided. This review aims to provide an up-to-date knowledge of the chemical structures, pharmacological activities, and chemical synthesis of the chemical constituents from soft corals of the genus Capnella.
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五十年来 Capnella 属软珊瑚次生代谢物概述:化学结构、药理活性、核磁共振数据和化学合成
迄今为止,还没有对 Capnella 属软珊瑚中的次生代谢物进行过专门研究。在这项工作中,描述了来自该属不同物种的所有次生代谢物。它涵盖了从 1974 年到 2024 年 5 月的首次工作,时间跨度长达五十年。从一般结构特征的角度,这些化学成分被分为四类:倍半萜、二萜、甾体和脂类。此外,还提供了这些代谢物的 1H 和 13C NMR 数据(如有文献提供)。其中,倍半萜是软珊瑚属植物中最丰富的化学成分。对这些化合物的多种药理活性进行了评估,如细胞毒性、抗菌、抗真菌和抗炎活性。此外,还提供了几种具有代表性的倍半萜的化学合成方法。本综述旨在提供有关帽贝属软珊瑚中化学成分的化学结构、药理活性和化学合成的最新知识。
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来源期刊
Marine Drugs
Marine Drugs 医学-医药化学
CiteScore
9.60
自引率
14.80%
发文量
671
审稿时长
1 months
期刊介绍: Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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